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Hydrophobic Regions on the Active Surface of Choline-esterases

Martin Izrailevich Kabachnik ^{1, 2, 3}

Martin Izrailevich Kabachnik

Abduvali Abdusamatovich Abduvakhabov ^{1, 2, 3}

Abduvali Abdusamatovich Abduvakhabov

I I Agabekova ^{1, 2, 3}

I I Agabekova

Aleksandr Pavlovich Brestkin ^{1, 2, 3}

Aleksandr Pavlovich Brestkin

Rimma Ivanovna Volkova ^{1, 2, 3}

Rimma Ivanovna Volkova

Nikolai Nikolaevich Godovikov ^{1, 2, 3}

Nikolai Nikolaevich Godovikov

E I Godyna ^{1, 2, 3}

E I Godyna

S S Mikhailov ^{1, 2, 3}

S S Mikhailov

M Ya Mikhel'son ^{1, 2, 3}

M Ya Mikhel'son

Viktor Iosifovich Rosengart ^{1, 2, 3}

Viktor Iosifovich Rosengart

Evgenii Viktorovich Rozengart ^{1, 2, 3}

Evgenii Viktorovich Rozengart

R V Sitkevich ^{1, 2, 3}

R V Sitkevich

¹ I. M. Sechenov Leningrad Institute of Evolutionary Physiology and Biochemistry

² A. N. Nesmeyanov Institute of Organoelement Compounds, USSR Academy of Sciences, Moscow

³ 1st Leningrad Medical Institute

10.1070/RC1970v039n06ABEH002001

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Published 30 November 1969

Communication , Volume 39, Issue 6, 485-497

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1970, Volume 39, Issue 6

1 June 1970

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Kabachnik M. I. et al. Hydrophobic Regions on the Active Surface of Choline-esterases // Russian Chemical Reviews. 1970. Vol. 39. No. 6. pp. 485-497.

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Kabachnik M. I., Abduvakhabov A. A., Agabekova I. I., Brestkin A. P., Volkova R. I., Godovikov N. N., Godyna E. I., Mikhailov S. S., Mikhel'son M. Ya., Rosengart V. I., Rozengart E. V., Sitkevich R. V. Hydrophobic Regions on the Active Surface of Choline-esterases // Russian Chemical Reviews. 1970. Vol. 39. No. 6. pp. 485-497.

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TY - JOUR

DO - 10.1070/RC1970v039n06ABEH002001

UR - https://rcr.colab.ws/publications/10.1070/RC1970v039n06ABEH002001

TI - Hydrophobic Regions on the Active Surface of Choline-esterases

T2 - Russian Chemical Reviews

AU - Kabachnik, Martin Izrailevich

AU - Abduvakhabov, Abduvali Abdusamatovich

AU - Agabekova, I I

AU - Brestkin, Aleksandr Pavlovich

AU - Volkova, Rimma Ivanovna

AU - Godovikov, Nikolai Nikolaevich

AU - Godyna, E I

AU - Mikhailov, S S

AU - Mikhel'son, M Ya

AU - Rosengart, Viktor Iosifovich

AU - Rozengart, Evgenii Viktorovich

AU - Sitkevich, R V

PY - 1970

DA - 1969/11/30

PB - ANO Editorial Board of the journal Uspekhi Khimii

SP - 485-497

IS - 6

VL - 39

ER -

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@article{1970_Kabachnik,

author = {Martin Izrailevich Kabachnik and Abduvali Abdusamatovich Abduvakhabov and I I Agabekova and Aleksandr Pavlovich Brestkin and Rimma Ivanovna Volkova and Nikolai Nikolaevich Godovikov and E I Godyna and S S Mikhailov and M Ya Mikhel'son and Viktor Iosifovich Rosengart and Evgenii Viktorovich Rozengart and R V Sitkevich},

title = {Hydrophobic Regions on the Active Surface of Choline-esterases},

journal = {Russian Chemical Reviews},

year = {1970},

volume = {39},

publisher = {ANO Editorial Board of the journal Uspekhi Khimii},

month = {Nov},

url = {https://rcr.colab.ws/publications/10.1070/RC1970v039n06ABEH002001},

number = {6},

pages = {485--497},

doi = {10.1070/RC1970v039n06ABEH002001}

}

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Kabachnik, Martin Izrailevich, et al. “Hydrophobic Regions on the Active Surface of Choline-esterases.” Russian Chemical Reviews, vol. 39, no. 6, Nov. 1970, pp. 485-497. https://rcr.colab.ws/publications/10.1070/RC1970v039n06ABEH002001.

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Abstract

The methods of synthesis of S-alkyl(aryl) derivatives of methylphosphonothioic acid and methods for the investigation of their anticholine-esterase activity have been briefly described. Data confirming the anticholine-esterase activity of the compounds synthesised are presented.
It has been shown that, in the inhibition of choline-esterases by organophosphorus compounds, the hydrophobic sorption of these substances on the active surface of the enzymes plays an important and sometimes a decisive role.
It is suggested that the presence of hydrophobic regions on the active surface of choline-esterases tends to increase the probability of the sorption of acetylcholine (a choline esterase substrate) on this surface.
The bibliography includes 68 references.