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Modification of DNA by Alkylating Compounds

Kira Evgen'evna Kruglyakova 1
Kira Evgen'evna Kruglyakova
1 Institute of Chemical Physics of the USSR Academy of Sciences, Moscow
10.1070/RC1985v054n09ABEH003120
Published 30 November 1984
Communication , Volume 54, Issue 9, 898-906
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Kruglyakova K. E. Modification of DNA by Alkylating Compounds // Russian Chemical Reviews. 1985. Vol. 54. No. 9. pp. 898-906.
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Kruglyakova K. E. Modification of DNA by Alkylating Compounds // Russian Chemical Reviews. 1985. Vol. 54. No. 9. pp. 898-906.
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TY - JOUR
DO - 10.1070/RC1985v054n09ABEH003120
UR - https://rcr.colab.ws/publications/10.1070/RC1985v054n09ABEH003120
TI - Modification of DNA by Alkylating Compounds
T2 - Russian Chemical Reviews
AU - Kruglyakova, Kira Evgen'evna
PY - 1985
DA - 1984/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 898-906
IS - 9
VL - 54
ER -
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@article{1985_Kruglyakova,
author = {Kira Evgen'evna Kruglyakova},
title = {Modification of DNA by Alkylating Compounds},
journal = {Russian Chemical Reviews},
year = {1985},
volume = {54},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RC1985v054n09ABEH003120},
number = {9},
pages = {898--906},
doi = {10.1070/RC1985v054n09ABEH003120}
}
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Kruglyakova, Kira Evgen'evna. “Modification of DNA by Alkylating Compounds.” Russian Chemical Reviews, vol. 54, no. 9, Nov. 1985, pp. 898-906. https://rcr.colab.ws/publications/10.1070/RC1985v054n09ABEH003120.
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Abstract

The results of studies of the physicochemical properties of alkylating compounds – alkylnitrosoureas (ANU) – with a broad spectrum of biological activities (mutagenic, carcinogenic, and antitumour) as a result of the alkylation and carbamoylation of DNA as well as other cell components are presented. The identified chemical products of the interaction of ANU with DNA and its components are listed. The structural transformations of the DNA macromolecules as a consequence of their chemical modification are examined and the possible biological consequences of the modification of DNA by ANU are discussed.
The bibliography includes 148 references.