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Kinetic isotope effects in the enzymic reactions of tritium- and deuterium-containing substrates

Gennadii Petrovich Akulov 1
Gennadii Petrovich Akulov
1 RPA 'V. G. Khlopin Radium Institute', St. Petersburg
10.1070/RC1992v061n10ABEH001012
Published 30 November 1991
Communication , Volume 61, Issue 10, 999-1008
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Akulov G. P. Kinetic isotope effects in the enzymic reactions of tritium- and deuterium-containing substrates // Russian Chemical Reviews. 1992. Vol. 61. No. 10. pp. 999-1008.
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Akulov G. P. Kinetic isotope effects in the enzymic reactions of tritium- and deuterium-containing substrates // Russian Chemical Reviews. 1992. Vol. 61. No. 10. pp. 999-1008.
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TY - JOUR
DO - 10.1070/RC1992v061n10ABEH001012
UR - https://rcr.colab.ws/publications/10.1070/RC1992v061n10ABEH001012
TI - Kinetic isotope effects in the enzymic reactions of tritium- and deuterium-containing substrates
T2 - Russian Chemical Reviews
AU - Akulov, Gennadii Petrovich
PY - 1992
DA - 1991/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 999-1008
IS - 10
VL - 61
ER -
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@article{1992_Akulov,
author = {Gennadii Petrovich Akulov},
title = {Kinetic isotope effects in the enzymic reactions of tritium- and deuterium-containing substrates},
journal = {Russian Chemical Reviews},
year = {1992},
volume = {61},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RC1992v061n10ABEH001012},
number = {10},
pages = {999--1008},
doi = {10.1070/RC1992v061n10ABEH001012}
}
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Akulov, Gennadii Petrovich. “Kinetic isotope effects in the enzymic reactions of tritium- and deuterium-containing substrates.” Russian Chemical Reviews, vol. 61, no. 10, Nov. 1992, pp. 999-1008. https://rcr.colab.ws/publications/10.1070/RC1992v061n10ABEH001012.
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Abstract

The kinetic differences between the enzymic reactions involving substrates containing heavy hydrogen isotopes are examined. Theoretical estimates and numerous examples of experimentally measured kinetic isotope effects in various enzymic reaction are presented. The kinetic isotope effects are widely used in studies of the mechanisms of enzymic reactions and of the structures of the enzyme–substrate complexes, for the enrichment of labelled compounds in heavy hydrogen isotopes, and also in certain fields of medicine and biochemistry.
The bibliography includes 99 references.