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The structural-functional organisation of natural peptides

Evgenii Mitrofanovich Popov 1
Evgenii Mitrofanovich Popov
1 Moscow State Correspondence Institute of Food Industry
Published 30 November 1993
Communication , Volume 63, Issue 11, 945-964
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Popov E. M. The structural-functional organisation of natural peptides // Russian Chemical Reviews. 1994. Vol. 63. No. 11. pp. 945-964.
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Popov E. M. The structural-functional organisation of natural peptides // Russian Chemical Reviews. 1994. Vol. 63. No. 11. pp. 945-964.
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TY - JOUR
DO - 10.1070/RC1994v063n11ABEH000128
UR - https://rcr.colab.ws/publications/10.1070/RC1994v063n11ABEH000128
TI - The structural-functional organisation of natural peptides
T2 - Russian Chemical Reviews
AU - Popov, Evgenii Mitrofanovich
PY - 1994
DA - 1993/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 945-964
IS - 11
VL - 63
ER -
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@article{1994_Popov,
author = {Evgenii Mitrofanovich Popov},
title = {The structural-functional organisation of natural peptides},
journal = {Russian Chemical Reviews},
year = {1994},
volume = {63},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RC1994v063n11ABEH000128},
number = {11},
pages = {945--964},
doi = {10.1070/RC1994v063n11ABEH000128}
}
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Popov, Evgenii Mitrofanovich. “The structural-functional organisation of natural peptides.” Russian Chemical Reviews, vol. 63, no. 11, Nov. 1994, pp. 945-964. https://rcr.colab.ws/publications/10.1070/RC1994v063n11ABEH000128.
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Abstract

The principles of the structural and structural-functional organisation of the molecules of natural oligopepetides are discussed. The approach to the investigation of the biological activity of peptide hormones directed from structure to function is discussed in general terms and in relation to angiotensin II. It is shown that the polyfunctionality of peptides arises from their ability to exist in a series of conformational states under physiological conditions. A separate function of the peptide is achieved by means of a conformation characteristic of only this function among the conformations most preferred for the free molecule. The method of specific construction of artificial analogues, the steric structure of which corresponds to the set of low-energy physiologically active conformational states of the natural hormone, is examined. The bibliography includes 104 references.

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