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Interaction of bleomycin and ist oligonucleotide derivatives with nucleic acids

Dmitrii Stanislavovich Sergeyev 1
Dmitrii Stanislavovich Sergeyev
, 
Valentina Filippovna Zarytova 1
Valentina Filippovna Zarytova
1 Novosibirsk Institute of Bioorganic Chemistry, Siberian Branch of the Russian Academy of Sciences
10.1070/RC1996v065n04ABEH000216
Published 30 November 1995
Communication , Volume 65, Issue 4, 355-378
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Sergeyev D. S., Zarytova V. F. Interaction of bleomycin and ist oligonucleotide derivatives with nucleic acids // Russian Chemical Reviews. 1996. Vol. 65. No. 4. pp. 355-378.
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Sergeyev D. S., Zarytova V. F. Interaction of bleomycin and ist oligonucleotide derivatives with nucleic acids // Russian Chemical Reviews. 1996. Vol. 65. No. 4. pp. 355-378.
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TY - JOUR
DO - 10.1070/RC1996v065n04ABEH000216
UR - https://rcr.colab.ws/publications/10.1070/RC1996v065n04ABEH000216
TI - Interaction of bleomycin and ist oligonucleotide derivatives with nucleic acids
T2 - Russian Chemical Reviews
AU - Sergeyev, Dmitrii Stanislavovich
AU - Zarytova, Valentina Filippovna
PY - 1996
DA - 1995/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 355-378
IS - 4
VL - 65
ER -
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@article{1996_Sergeyev,
author = {Dmitrii Stanislavovich Sergeyev and Valentina Filippovna Zarytova},
title = {Interaction of bleomycin and ist oligonucleotide derivatives with nucleic acids},
journal = {Russian Chemical Reviews},
year = {1996},
volume = {65},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RC1996v065n04ABEH000216},
number = {4},
pages = {355--378},
doi = {10.1070/RC1996v065n04ABEH000216}
}
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Sergeyev, Dmitrii Stanislavovich, and Valentina Filippovna Zarytova. “Interaction of bleomycin and ist oligonucleotide derivatives with nucleic acids.” Russian Chemical Reviews, vol. 65, no. 4, Nov. 1996, pp. 355-378. https://rcr.colab.ws/publications/10.1070/RC1996v065n04ABEH000216.
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Abstract

Various aspects of interaction of the antitumour glycopeptide antibiotic bleomycin with nucleic acids are considered. Data on equilibrium binding parameters obtained by various physicochemical methods have been collected and compared. The contribution of N- and C-terminal domains of the glycopeptide molecule to the binding with DNA and sequence specificity of DNA cleavage are discussed. Data on a recently created new class of compounds – bleomycin – oligonucleotide conjugates – are presented. These compounds, like antibiotics, possess DNA-cleaving activity (also in a catalytic manner) together with high selectivity towards a selected nucleotide sequence. The bibliography includes 267 references.

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