Home / Articles / Solid-phase method for tritium labelling of biologically active compounds

Solid-phase method for tritium labelling of biologically active compounds

Valerii Pavlovich Shevchenko 1
Valerii Pavlovich Shevchenko
, 
Igor Yulianovich Nagaev 1
Igor Yulianovich Nagaev
, 
Nikolai Fedorovich Myasoedov 1
Nikolai Fedorovich Myasoedov
1 Institute of Molecular Genetics of the Russian Academy of Sciences
10.1070/RC2003v072n05ABEH000781
Published 30 November 2002
Communication , Volume 72, Issue 5, 423-446
25
Share
Cite this
GOST
 | 
Cite this
GOST
Copy cite
Shevchenko V. P., Nagaev I. Y., Myasoedov N. F. Solid-phase method for tritium labelling of biologically active compounds // Russian Chemical Reviews. 2003. Vol. 72. No. 5. pp. 423-446.
GOST all authors (up to 50)
Copy cite
Shevchenko V. P., Nagaev I. Y., Myasoedov N. F. Solid-phase method for tritium labelling of biologically active compounds // Russian Chemical Reviews. 2003. Vol. 72. No. 5. pp. 423-446.
RIS
 | 
Cite this
RIS
Copy cite
TY - JOUR
DO - 10.1070/RC2003v072n05ABEH000781
UR - https://rcr.colab.ws/publications/10.1070/RC2003v072n05ABEH000781
TI - Solid-phase method for tritium labelling of biologically active compounds
T2 - Russian Chemical Reviews
AU - Shevchenko, Valerii Pavlovich
AU - Nagaev, Igor Yulianovich
AU - Myasoedov, Nikolai Fedorovich
PY - 2003
DA - 2002/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 423-446
IS - 5
VL - 72
ER -
BibTex
 | 
Cite this
BibTex (up to 50 authors)
Copy cite
@article{2003_Shevchenko,
author = {Valerii Pavlovich Shevchenko and Igor Yulianovich Nagaev and Nikolai Fedorovich Myasoedov},
title = {Solid-phase method for tritium labelling of biologically active compounds},
journal = {Russian Chemical Reviews},
year = {2003},
volume = {72},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RC2003v072n05ABEH000781},
number = {5},
pages = {423--446},
doi = {10.1070/RC2003v072n05ABEH000781}
}
MLA
Cite this
MLA
Copy cite
Shevchenko, Valerii Pavlovich, et al. “Solid-phase method for tritium labelling of biologically active compounds.” Russian Chemical Reviews, vol. 72, no. 5, Nov. 2003, pp. 423-446. https://rcr.colab.ws/publications/10.1070/RC2003v072n05ABEH000781.
Views / Visits / Downloads
15 / 15 / 2

Abstract

The solid-phase method for conducting hydrogenolysis, hydrogenation and isotope exchange reactions is described. The potential of the solid-phase method for tritium labelling of various organic compounds including lipids, nucleotides, amino acids, peptides, etc. is demonstrated. The influence of the reaction conditions on the yield and on the molar radioactivity of the labelled specimens is considered. It is shown that the results obtained can be interpreted by the dependence of tritium spillover on the nature of the initial compound and other factors.