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Nitric oxide synthase inhibitors containing the carboxamidine group or its isosteres

Sergei Yakovlevich Proskuryakov 1
Sergei Yakovlevich Proskuryakov
, 
Anatoly Georgievich Konoplyannikov 1
Anatoly Georgievich Konoplyannikov
, 
Valery Grigor'evich Skvortzov 1
Valery Grigor'evich Skvortzov
, 
Andrey Aleksandrovich Mandrugin 2
Andrey Aleksandrovich Mandrugin
, 
Vladimir Mikhailovich Fedoseev 2
Vladimir Mikhailovich Fedoseev
1 Medical Radiological Scientific Center, Russian Academy of Medical Sciences, Obninsk, Kaluzhskaya obl.
2 Lomonosov Moscow State University, Faculty of Chemistry
10.1070/RC2005v074n09ABEH000923
Published 30 November 2004
Communication , Volume 74, Issue 9, 859-870
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Proskuryakov S. Y. et al. Nitric oxide synthase inhibitors containing the carboxamidine group or its isosteres // Russian Chemical Reviews. 2005. Vol. 74. No. 9. pp. 859-870.
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Proskuryakov S. Y., Konoplyannikov A. G., Skvortzov V. G., Mandrugin A. A., Fedoseev V. M. Nitric oxide synthase inhibitors containing the carboxamidine group or its isosteres // Russian Chemical Reviews. 2005. Vol. 74. No. 9. pp. 859-870.
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TY - JOUR
DO - 10.1070/RC2005v074n09ABEH000923
UR - https://rcr.colab.ws/publications/10.1070/RC2005v074n09ABEH000923
TI - Nitric oxide synthase inhibitors containing the carboxamidine group or its isosteres
T2 - Russian Chemical Reviews
AU - Proskuryakov, Sergei Yakovlevich
AU - Konoplyannikov, Anatoly Georgievich
AU - Skvortzov, Valery Grigor'evich
AU - Mandrugin, Andrey Aleksandrovich
AU - Fedoseev, Vladimir Mikhailovich
PY - 2005
DA - 2004/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 859-870
IS - 9
VL - 74
ER -
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@article{2005_Proskuryakov,
author = {Sergei Yakovlevich Proskuryakov and Anatoly Georgievich Konoplyannikov and Valery Grigor'evich Skvortzov and Andrey Aleksandrovich Mandrugin and Vladimir Mikhailovich Fedoseev},
title = {Nitric oxide synthase inhibitors containing the carboxamidine group or its isosteres},
journal = {Russian Chemical Reviews},
year = {2005},
volume = {74},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RC2005v074n09ABEH000923},
number = {9},
pages = {859--870},
doi = {10.1070/RC2005v074n09ABEH000923}
}
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Proskuryakov, Sergei Yakovlevich, et al. “Nitric oxide synthase inhibitors containing the carboxamidine group or its isosteres.” Russian Chemical Reviews, vol. 74, no. 9, Nov. 2005, pp. 859-870. https://rcr.colab.ws/publications/10.1070/RC2005v074n09ABEH000923.
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Abstract

The review summarises structures, activities and selectivity of NO-synthase (NOS) inhibitors belonging to various classes of chemical compounds. Linear, cyclic and heterocyclic structures containing guanidine, amidine and/or isothiourea fragments are considered. The structure–activity relationships for these inhibitors were analysed in relation to their action on the inducible NOS isoform. This analysis can provide the basis for the synthesis of new more efficient compounds.