Home / Articles / Enediyne antibiotics and their models: new potential of acetylene chemistry

Enediyne antibiotics and their models: new potential of acetylene chemistry

Irina Aleksandrovna Maretina 1
Irina Aleksandrovna Maretina
, 
1 A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
10.1070/RC2006v075n09ABEH002479
Published 30 November 2005
Communication , Volume 75, Issue 9, 825-845
42
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Maretina I. A., Trofimov B. A. Enediyne antibiotics and their models: new potential of acetylene chemistry // Russian Chemical Reviews. 2006. Vol. 75. No. 9. pp. 825-845.
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Maretina I. A., Trofimov B. A. Enediyne antibiotics and their models: new potential of acetylene chemistry // Russian Chemical Reviews. 2006. Vol. 75. No. 9. pp. 825-845.
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TY - JOUR
DO - 10.1070/RC2006v075n09ABEH002479
UR - https://rcr.colab.ws/publications/10.1070/RC2006v075n09ABEH002479
TI - Enediyne antibiotics and their models: new potential of acetylene chemistry
T2 - Russian Chemical Reviews
AU - Maretina, Irina Aleksandrovna
AU - Trofimov, Boris Aleksandrovich
PY - 2006
DA - 2005/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 825-845
IS - 9
VL - 75
ER -
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@article{2006_Maretina,
author = {Irina Aleksandrovna Maretina and Boris Aleksandrovich Trofimov},
title = {Enediyne antibiotics and their models: new potential of acetylene chemistry},
journal = {Russian Chemical Reviews},
year = {2006},
volume = {75},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RC2006v075n09ABEH002479},
number = {9},
pages = {825--845},
doi = {10.1070/RC2006v075n09ABEH002479}
}
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Maretina, Irina Aleksandrovna, and Boris Aleksandrovich Trofimov. “Enediyne antibiotics and their models: new potential of acetylene chemistry.” Russian Chemical Reviews, vol. 75, no. 9, Nov. 2006, pp. 825-845. https://rcr.colab.ws/publications/10.1070/RC2006v075n09ABEH002479.
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Abstract

Structures and chemical properties of enediynes, viz., compounds comprising a system of conjugated double and triple bonds, are surveyed. The presence of this system in the molecules of enediyne antitumour antibiotics ensures their high activity. The mechanism of biological action of enediynes is discussed based on cycloaromatisation of the enediyne chromophore resulting in highly active benzenoid 1,4-diradicals, which selectively cleave DNA. The key strategies of enediyne synthesis are analysed.