Ion-selective electrodes in medicinal drug determination

Data published in the past 10 years on the use of ion-selective electrodes in direct potentiometry and potentiometric titration for the determination of organic medicinal drugs are analysed. In the vast majority of cases, ion-sensitive membranes contain associates of drug cations or anions with appropriate counter-ions. The theoretical approaches to optimisation of the characteristics of ion-selective electrodes are discussed. The mechanism of electrode response generation for neutral and charged carriers of organic ions is considered.