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Multifunctional compounds containing organic nitrates as prototypes of hybrid drugs

Igor Viktorovich Serkov 1
Igor Viktorovich Serkov
, 
Vladimir Vilenovich Bezuglov 2
Vladimir Vilenovich Bezuglov
1 Institute of Physiologically Active Compounds RAS, Chernogolovka
2 Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow
10.1070/RC2009v078n05ABEH004024
Published 30 November 2008
Communication , Volume 78, Issue 5, 407-429
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Serkov I. V., Bezuglov V. V. Multifunctional compounds containing organic nitrates as prototypes of hybrid drugs // Russian Chemical Reviews. 2009. Vol. 78. No. 5. pp. 407-429.
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Serkov I. V., Bezuglov V. V. Multifunctional compounds containing organic nitrates as prototypes of hybrid drugs // Russian Chemical Reviews. 2009. Vol. 78. No. 5. pp. 407-429.
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TY - JOUR
DO - 10.1070/RC2009v078n05ABEH004024
UR - https://rcr.colab.ws/publications/10.1070/RC2009v078n05ABEH004024
TI - Multifunctional compounds containing organic nitrates as prototypes of hybrid drugs
T2 - Russian Chemical Reviews
AU - Serkov, Igor Viktorovich
AU - Bezuglov, Vladimir Vilenovich
PY - 2009
DA - 2008/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 407-429
IS - 5
VL - 78
ER -
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@article{2009_Serkov,
author = {Igor Viktorovich Serkov and Vladimir Vilenovich Bezuglov},
title = {Multifunctional compounds containing organic nitrates as prototypes of hybrid drugs},
journal = {Russian Chemical Reviews},
year = {2009},
volume = {78},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RC2009v078n05ABEH004024},
number = {5},
pages = {407--429},
doi = {10.1070/RC2009v078n05ABEH004024}
}
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Serkov, Igor Viktorovich, and Vladimir Vilenovich Bezuglov. “Multifunctional compounds containing organic nitrates as prototypes of hybrid drugs.” Russian Chemical Reviews, vol. 78, no. 5, Nov. 2009, pp. 407-429. https://rcr.colab.ws/publications/10.1070/RC2009v078n05ABEH004024.
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Abstract

The modern trend in medicinal chemistry consists of designing multifunctional drugs with a wide variety of targets. This review considers one of the ways of development of such drugs, namely, the introduction of nitrogen monoxide-generating fragments into molecules of known drugs. Examples of syntheses and the results of biological activity assays are shown for O-nitro derivatives of various drugs.