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Artificial hammerhead ribozymes: engineering and applications

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Anna Sergeevna Davydova 1
Anna Sergeevna Davydova
, 
Aliya Gusein Kyzy Venyaminova 1
Aliya Gusein Kyzy Venyaminova
1 Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk
10.1070/RC2011v080n02ABEH004142
Published 30 November 2010
Communication , Volume 80, Issue 2, 127-143
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Vorobjeva M. A., Davydova A. S., Venyaminova A. G. K. Artificial hammerhead ribozymes: engineering and applications // Russian Chemical Reviews. 2011. Vol. 80. No. 2. pp. 127-143.
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Vorobjeva M. A., Davydova A. S., Venyaminova A. G. K. Artificial hammerhead ribozymes: engineering and applications // Russian Chemical Reviews. 2011. Vol. 80. No. 2. pp. 127-143.
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TY - JOUR
DO - 10.1070/RC2011v080n02ABEH004142
UR - https://rcr.colab.ws/publications/10.1070/RC2011v080n02ABEH004142
TI - Artificial hammerhead ribozymes: engineering and applications
T2 - Russian Chemical Reviews
AU - Vorobjeva, Maria Aleksandrovna
AU - Davydova, Anna Sergeevna
AU - Venyaminova, Aliya Gusein Kyzy
PY - 2011
DA - 2010/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 127-143
IS - 2
VL - 80
ER -
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@article{2011_Vorobjeva,
author = {Maria Aleksandrovna Vorobjeva and Anna Sergeevna Davydova and Aliya Gusein Kyzy Venyaminova},
title = {Artificial hammerhead ribozymes: engineering and applications},
journal = {Russian Chemical Reviews},
year = {2011},
volume = {80},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RC2011v080n02ABEH004142},
number = {2},
pages = {127--143},
doi = {10.1070/RC2011v080n02ABEH004142}
}
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Vorobjeva, Maria Aleksandrovna, et al. “Artificial hammerhead ribozymes: engineering and applications.” Russian Chemical Reviews, vol. 80, no. 2, Nov. 2011, pp. 127-143. https://rcr.colab.ws/publications/10.1070/RC2011v080n02ABEH004142.
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Abstract

The properties of hammerhead ribozymes are described. Various hammerhead ribozyme constructs for target RNA cleavage were considered. Approaches to enhancement of the stability of artificial ribozymes in biological media and to regulation of the catalytic activity of hammerhead ribozymes using effector molecules are described. The effect of ribozymes on extended structured natural RNAs is discussed. Applications of artificial hammerhead ribozymes as inhibitors of gene expression at matrix RNA level were considered.