Home / Articles / Development of concepts on the interaction of drugs with opioid receptors

Development of concepts on the interaction of drugs with opioid receptors

Natalia Evgen'evna Kuzmina 1
Natalia Evgen'evna Kuzmina
, 
Vladimir Semenovich Kuzmin 2
Vladimir Semenovich Kuzmin
1 State Scientific-Research Institute of Organic Chemistry and Technology
2 I. M. Sechenov First Moscow State Medical University
10.1070/RC2011v080n02ABEH004171
Published 30 November 2010
Communication , Volume 80, Issue 2, 145-169
6
Share
Cite this
GOST
 | 
Cite this
GOST
Copy cite
Kuzmina N. E., Kuzmin V. S. Development of concepts on the interaction of drugs with opioid receptors // Russian Chemical Reviews. 2011. Vol. 80. No. 2. pp. 145-169.
GOST all authors (up to 50)
Copy cite
Kuzmina N. E., Kuzmin V. S. Development of concepts on the interaction of drugs with opioid receptors // Russian Chemical Reviews. 2011. Vol. 80. No. 2. pp. 145-169.
RIS
 | 
Cite this
RIS
Copy cite
TY - JOUR
DO - 10.1070/RC2011v080n02ABEH004171
UR - https://rcr.colab.ws/publications/10.1070/RC2011v080n02ABEH004171
TI - Development of concepts on the interaction of drugs with opioid receptors
T2 - Russian Chemical Reviews
AU - Kuzmina, Natalia Evgen'evna
AU - Kuzmin, Vladimir Semenovich
PY - 2011
DA - 2010/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 145-169
IS - 2
VL - 80
ER -
BibTex
 | 
Cite this
BibTex (up to 50 authors)
Copy cite
@article{2011_Kuzmina,
author = {Natalia Evgen'evna Kuzmina and Vladimir Semenovich Kuzmin},
title = {Development of concepts on the interaction of drugs with opioid receptors},
journal = {Russian Chemical Reviews},
year = {2011},
volume = {80},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RC2011v080n02ABEH004171},
number = {2},
pages = {145--169},
doi = {10.1070/RC2011v080n02ABEH004171}
}
MLA
Cite this
MLA
Copy cite
Kuzmina, Natalia Evgen'evna, and Vladimir Semenovich Kuzmin. “Development of concepts on the interaction of drugs with opioid receptors.” Russian Chemical Reviews, vol. 80, no. 2, Nov. 2011, pp. 145-169. https://rcr.colab.ws/publications/10.1070/RC2011v080n02ABEH004171.
Views / Visits / Downloads
17 / 17 / 4

Abstract

The development of concepts on the molecular mechanisms of the action of medicinal drugs on the opioid receptors is briefly surveyed. The modern point of view on the mechanism of activation of opioid receptors is given based on the data from chimeric and site-directed mutagenesis of the cloned opioid receptors and the computer-aided simulations of the reception zone and ligand–receptor complexes. Three-dimensional models of the opioid pharmacophore derived by both conventional methods and a comparative analysis of molecular fields are described in detail.