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Sulfonyl modulators of serotonin 5-HT$_{6}$ receptors and their pharmacophore models

Aleksandr Vasil'evich Ivachtchenko 1, 2, 3
Aleksandr Vasil'evich Ivachtchenko
1 Chemical Diversity Research Institute
2 ChemDiv, Inc.
3 Aniveuro Pharmaceuticals, Inc., San Diego, CA, USA
10.1070/RC2014v083n05ABEH004371
Published 30 November 2013
Communication , Volume 83, Issue 5, 439-473
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Ivachtchenko A. V. Sulfonyl modulators of serotonin 5-HT$_{6}$ receptors and their pharmacophore models // Russian Chemical Reviews. 2014. Vol. 83. No. 5. pp. 439-473.
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Ivachtchenko A. V. Sulfonyl modulators of serotonin 5-HT$_{6}$ receptors and their pharmacophore models // Russian Chemical Reviews. 2014. Vol. 83. No. 5. pp. 439-473.
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TY - JOUR
DO - 10.1070/RC2014v083n05ABEH004371
UR - https://rcr.colab.ws/publications/10.1070/RC2014v083n05ABEH004371
TI - Sulfonyl modulators of serotonin 5-HT$_{6}$ receptors and their pharmacophore models
T2 - Russian Chemical Reviews
AU - Ivachtchenko, Aleksandr Vasil'evich
PY - 2014
DA - 2013/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 439-473
IS - 5
VL - 83
ER -
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@article{2014_Ivachtchenko,
author = {Aleksandr Vasil'evich Ivachtchenko},
title = {Sulfonyl modulators of serotonin 5-HT$_{6}$ receptors and their pharmacophore models},
journal = {Russian Chemical Reviews},
year = {2014},
volume = {83},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RC2014v083n05ABEH004371},
number = {5},
pages = {439--473},
doi = {10.1070/RC2014v083n05ABEH004371}
}
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Ivachtchenko, Aleksandr Vasil'evich. “Sulfonyl modulators of serotonin 5-HT$_{6}$ receptors and their pharmacophore models.” Russian Chemical Reviews, vol. 83, no. 5, Nov. 2014, pp. 439-473. https://rcr.colab.ws/publications/10.1070/RC2014v083n05ABEH004371.
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Abstract

The data on the syntheses of serotonin 5-HT$_{6}$ receptor modulators published in recent years are surveyed. Modulators with high affinity to 5-HT$_{6}$ receptors with different selectivity degrees ranging from highly selective to semi selective and multimodal are described. The results of clinical trials of the most promising 5-HT$_{6}$ receptor modulators that arouse most interest in medicinal chemists are also described.

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