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Anti-ulcer agents: chemical aspect of solving the problem

Ludmila Nikolaevna Rogoza 1
Ludmila Nikolaevna Rogoza
, 
Nariman Faridovich Salakhutdinov 1
Nariman Faridovich Salakhutdinov
1 N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistryof the Siberian Branch of Russian Academy of Sciences
10.1070/RCR4430
Published 30 November 2014
Communication , Volume 84, Issue 1, 98-120
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Rogoza L. N., Salakhutdinov N. F. Anti-ulcer agents: chemical aspect of solving the problem // Russian Chemical Reviews. 2015. Vol. 84. No. 1. pp. 98-120.
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Rogoza L. N., Salakhutdinov N. F. Anti-ulcer agents: chemical aspect of solving the problem // Russian Chemical Reviews. 2015. Vol. 84. No. 1. pp. 98-120.
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TY - JOUR
DO - 10.1070/RCR4430
UR - https://rcr.colab.ws/publications/10.1070/RCR4430
TI - Anti-ulcer agents: chemical aspect of solving the problem
T2 - Russian Chemical Reviews
AU - Rogoza, Ludmila Nikolaevna
AU - Salakhutdinov, Nariman Faridovich
PY - 2015
DA - 2014/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 98-120
IS - 1
VL - 84
ER -
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@article{2015_Rogoza,
author = {Ludmila Nikolaevna Rogoza and Nariman Faridovich Salakhutdinov},
title = {Anti-ulcer agents: chemical aspect of solving the problem},
journal = {Russian Chemical Reviews},
year = {2015},
volume = {84},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR4430},
number = {1},
pages = {98--120},
doi = {10.1070/RCR4430}
}
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Rogoza, Ludmila Nikolaevna, and Nariman Faridovich Salakhutdinov. “Anti-ulcer agents: chemical aspect of solving the problem.” Russian Chemical Reviews, vol. 84, no. 1, Nov. 2015, pp. 98-120. https://rcr.colab.ws/publications/10.1070/RCR4430.
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Abstract

The data on chemical structures and specific activities of compounds functioning as histamine $H_2$-receptor antagonists, H+/K+-ATPase inhibitors at the exchange sites of hydrogen ions (proton pump inhibitors) and potassium ions (K+-competitive acid blockers) published from 1990 to 2013 are surveyed. The antisecretory agents with studied cytoprotective activity or with additional therapeutic properties compensating for disorders of internal defence mechanisms are presented. A separate section is devoted to the drugs that prevent or mitigate the NSAID-induced intestinal damage. All of the considered structures are classified according to the type of biological mechanism of action. Some aspects of the structure--activity relationships for such compounds are considered. The bibliography includes 83 references.

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