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Design of dual action antibiotics as an approach to search for new promising drugs

Anna Nikolaevna Tevyashova 1
Anna Nikolaevna Tevyashova
, 
Evgeniya Nikolaevna Olsufyeva 1
Evgeniya Nikolaevna Olsufyeva
, 
Mariya Nikolaevna Preobrazhenskaya 1
Mariya Nikolaevna Preobrazhenskaya
1 G. F. Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, Moscow
10.1070/RCR4448
Published 30 November 2014
Communication , Volume 84, Issue 1, 61-97
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Tevyashova A. N., Olsufyeva E. N., Preobrazhenskaya M. N. Design of dual action antibiotics as an approach to search for new promising drugs // Russian Chemical Reviews. 2015. Vol. 84. No. 1. pp. 61-97.
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Tevyashova A. N., Olsufyeva E. N., Preobrazhenskaya M. N. Design of dual action antibiotics as an approach to search for new promising drugs // Russian Chemical Reviews. 2015. Vol. 84. No. 1. pp. 61-97.
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TY - JOUR
DO - 10.1070/RCR4448
UR - https://rcr.colab.ws/publications/10.1070/RCR4448
TI - Design of dual action antibiotics as an approach to search for new promising drugs
T2 - Russian Chemical Reviews
AU - Tevyashova, Anna Nikolaevna
AU - Olsufyeva, Evgeniya Nikolaevna
AU - Preobrazhenskaya, Mariya Nikolaevna
PY - 2015
DA - 2014/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 61-97
IS - 1
VL - 84
ER -
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@article{2015_Tevyashova,
author = {Anna Nikolaevna Tevyashova and Evgeniya Nikolaevna Olsufyeva and Mariya Nikolaevna Preobrazhenskaya},
title = {Design of dual action antibiotics as an approach to search for new promising drugs},
journal = {Russian Chemical Reviews},
year = {2015},
volume = {84},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR4448},
number = {1},
pages = {61--97},
doi = {10.1070/RCR4448}
}
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Tevyashova, Anna Nikolaevna, et al. “Design of dual action antibiotics as an approach to search for new promising drugs.” Russian Chemical Reviews, vol. 84, no. 1, Nov. 2015, pp. 61-97. https://rcr.colab.ws/publications/10.1070/RCR4448.
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Abstract

The review is devoted to the latest achievements in the design of dual action antibiotics --- heterodimeric (chimeric) structures based on antibacterial agents of different classes (fluoroquinolones, anthracyclines, oxazolidines, macrolides and so on). Covalent binding can make the pharmacokinetic characteristics of these molecules more predictable and improve the penetration of each component into the cell. Consequently, not only does the drug efficacy increase owing to inhibition of two targets but also the resistance to one or both antibiotics can be overcome. The theoretical grounds of elaboration, design principles and methods for the synthesis of dual action antibiotics are considered. The structures are classified according to the type of covalent spacer (cleavable or not) connecting the moieties of two agents. Dual action antibiotics with a spacer that can be cleaved in a living cell are considered as dual action prodrugs. Data on the biological action of heterodimeric compounds are presented and structure--activity relationships are analyzed.

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