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Recent advances in isoxazole chemistry

Aleksey Victorovich Galenko 1
Aleksey Victorovich Galenko
, 
Alexander Fedorovich Khlebnikov 1
Alexander Fedorovich Khlebnikov
,  , 
Viktoriya Valeryevna Pakalnis 1
Viktoriya Valeryevna Pakalnis
, 
Nikolay Vitalyevich Rostovskii 1
Nikolay Vitalyevich Rostovskii
1 Institute of Chemistry, St. Petersburg State University
10.1070/RCR4503
Published 30 November 2014
Communication , Volume 84, Issue 4, 335-377
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Galenko A. V. et al. Recent advances in isoxazole chemistry // Russian Chemical Reviews. 2015. Vol. 84. No. 4. pp. 335-377.
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Galenko A. V., Khlebnikov A. F., Novikov M. S., Pakalnis V. V., Rostovskii N. V. Recent advances in isoxazole chemistry // Russian Chemical Reviews. 2015. Vol. 84. No. 4. pp. 335-377.
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TY - JOUR
DO - 10.1070/RCR4503
UR - https://rcr.colab.ws/publications/10.1070/RCR4503
TI - Recent advances in isoxazole chemistry
T2 - Russian Chemical Reviews
AU - Galenko, Aleksey Victorovich
AU - Khlebnikov, Alexander Fedorovich
AU - Novikov, Mikhail Sergeyevich
AU - Pakalnis, Viktoriya Valeryevna
AU - Rostovskii, Nikolay Vitalyevich
PY - 2015
DA - 2014/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 335-377
IS - 4
VL - 84
ER -
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@article{2015_Galenko,
author = {Aleksey Victorovich Galenko and Alexander Fedorovich Khlebnikov and Mikhail Sergeyevich Novikov and Viktoriya Valeryevna Pakalnis and Nikolay Vitalyevich Rostovskii},
title = {Recent advances in isoxazole chemistry},
journal = {Russian Chemical Reviews},
year = {2015},
volume = {84},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR4503},
number = {4},
pages = {335--377},
doi = {10.1070/RCR4503}
}
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Galenko, Aleksey Victorovich, et al. “Recent advances in isoxazole chemistry.” Russian Chemical Reviews, vol. 84, no. 4, Nov. 2015, pp. 335-377. https://rcr.colab.ws/publications/10.1070/RCR4503.
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Abstract

The preparation methods and reactions of isoxazoles are described and systematized on the basis of analysis of the literature published from 2005 to present. In the discussion of synthesis, major attention is focused on the most efficient approaches: condensation of hydroxylamine with 1,3-dielectrophiles and reactions of nitrile oxides with alkenes and alkynes. Five-membered ring opening reactions leading to acyclic functionalized or other heterocyclic compounds are considered. The transformations of isoxazole derivatives that occur without ring cleavage to form fused heterocyclic systems, as well as reactions that lead to the introduction of C-substituents into isoxazoles, are considered. Data on the biological activity of some isoxazole derivatives are reported.

The bibliography includes 439 references.

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