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Synthesis and biological properties of amino acids and peptides containing a tetrazolyl moiety

Elena Aleksandrovna Popova 1
Elena Aleksandrovna Popova
, 
Rostislav Evgen'evich Trifonov 1
Rostislav Evgen'evich Trifonov
1 Saint Petersburg State University
10.1070/RCR4527
Published 30 November 2014
Communication , Volume 84, Issue 9, 891-916
43
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Popova E. A., Trifonov R. E. Synthesis and biological properties of amino acids and peptides containing a tetrazolyl moiety // Russian Chemical Reviews. 2015. Vol. 84. No. 9. pp. 891-916.
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Popova E. A., Trifonov R. E. Synthesis and biological properties of amino acids and peptides containing a tetrazolyl moiety // Russian Chemical Reviews. 2015. Vol. 84. No. 9. pp. 891-916.
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TY - JOUR
DO - 10.1070/RCR4527
UR - https://rcr.colab.ws/publications/10.1070/RCR4527
TI - Synthesis and biological properties of amino acids and peptides containing a tetrazolyl moiety
T2 - Russian Chemical Reviews
AU - Popova, Elena Aleksandrovna
AU - Trifonov, Rostislav Evgen'evich
PY - 2015
DA - 2014/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 891-916
IS - 9
VL - 84
ER -
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@article{2015_Popova,
author = {Elena Aleksandrovna Popova and Rostislav Evgen'evich Trifonov},
title = {Synthesis and biological properties of amino acids and peptides containing a tetrazolyl moiety},
journal = {Russian Chemical Reviews},
year = {2015},
volume = {84},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR4527},
number = {9},
pages = {891--916},
doi = {10.1070/RCR4527}
}
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Popova, Elena Aleksandrovna, and Rostislav Evgen'evich Trifonov. “Synthesis and biological properties of amino acids and peptides containing a tetrazolyl moiety.” Russian Chemical Reviews, vol. 84, no. 9, Nov. 2015, pp. 891-916. https://rcr.colab.ws/publications/10.1070/RCR4527.
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Abstract

Literature data published mainly in the last 15~years on the synthesis and biological properties of amino acid analogues and derivatives containing tetrazolyl moieties are analyzed. Tetrazolyl analogues and derivatives of amino acids and peptides are shown to be promising for medicinal chemistry. Being polynitrogen heterocyclic systems comprising four endocyclic nitrogen atoms, tetrazoles can behave as acids and bases and form strong hydrogen bonds with proton donors (more rarely, with acceptors). They have high metabolic stability and are able to penetrate biological membranes. The review also considers the synthesis and properties of linear and cyclic peptides based on modified amino acids incorporating a tetrazolyl moiety. A special issue is the discussion of the biological properties of tetrazole-containing amino acids and peptides, which exhibit high biological activity and can be used to design new drugs.

The bibliography includes 200~references.

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