Home / Articles / Development of approaches to a third-generation carbohydrate-conjugate vaccine against {\it Streptococcus pneumoniae}: the search for optimal oligosaccharide ligands

Development of approaches to a third-generation carbohydrate-conjugate vaccine against {\it Streptococcus pneumoniae}: the search for optimal oligosaccharide ligands

Marina Leonidovna Gening 1
Marina Leonidovna Gening
, 
E A Kurbatova 2
E A Kurbatova
, 
Yury Evgen'evich Tsvetkov 1
Yury Evgen'evich Tsvetkov
, 
Nikolay Eduardovich Nifantiev 1
Nikolay Eduardovich Nifantiev
1 N.D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences
2 I.I. Mechnikov Research Institute for Vaccines and Sera
10.1070/RCR4574
Published 30 November 2014
Communication , Volume 84, Issue 11, 1100-1113
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Gening M. L. et al. Development of approaches to a third-generation carbohydrate-conjugate vaccine against {\it Streptococcus pneumoniae}: the search for optimal oligosaccharide ligands // Russian Chemical Reviews. 2015. Vol. 84. No. 11. pp. 1100-1113.
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Gening M. L., Kurbatova E. A., Tsvetkov Y. E., Nifantiev N. E. Development of approaches to a third-generation carbohydrate-conjugate vaccine against {\it Streptococcus pneumoniae}: the search for optimal oligosaccharide ligands // Russian Chemical Reviews. 2015. Vol. 84. No. 11. pp. 1100-1113.
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TY - JOUR
DO - 10.1070/RCR4574
UR - https://rcr.colab.ws/publications/10.1070/RCR4574
TI - Development of approaches to a third-generation carbohydrate-conjugate vaccine against {\it Streptococcus pneumoniae}: the search for optimal oligosaccharide ligands
T2 - Russian Chemical Reviews
AU - Gening, Marina Leonidovna
AU - Kurbatova, E A
AU - Tsvetkov, Yury Evgen'evich
AU - Nifantiev, Nikolay Eduardovich
PY - 2015
DA - 2014/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 1100-1113
IS - 11
VL - 84
ER -
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@article{2015_Gening,
author = {Marina Leonidovna Gening and E A Kurbatova and Yury Evgen'evich Tsvetkov and Nikolay Eduardovich Nifantiev},
title = {Development of approaches to a third-generation carbohydrate-conjugate vaccine against {\it Streptococcus pneumoniae}: the search for optimal oligosaccharide ligands},
journal = {Russian Chemical Reviews},
year = {2015},
volume = {84},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR4574},
number = {11},
pages = {1100--1113},
doi = {10.1070/RCR4574}
}
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Gening, Marina Leonidovna, et al. “Development of approaches to a third-generation carbohydrate-conjugate vaccine against {\it Streptococcus pneumoniae}: the search for optimal oligosaccharide ligands.” Russian Chemical Reviews, vol. 84, no. 11, Nov. 2015, pp. 1100-1113. https://rcr.colab.ws/publications/10.1070/RCR4574.
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Abstract

The review addresses the application of synthetic oligosaccharides related to fragments of capsular polysaccharides from different serotypes of the bacterium {\it Streptococcus pneumoniae} for the design of third-generation pneumococcal conjugate vaccines. Special focus is given to characteristic features of the chemical structures of oligosaccharides required for the induction of the protective immune response when using synthetic glycoconjugate vaccines based on oligosaccharide ligands and carrier proteins.

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