Abstract
The review summarizes published data on the results and achievements in the field of structure and function analysis of protein--nucleic acid complexes by means of main physical and biochemical methods, including X-ray diffraction, nuclear magnetic resonance spectroscopy, electron and atomic force microscopy, small-angle X-ray and neutron scattering, footprinting and cross-linking. Special attention is given to combined approaches. The advantages and limitations of each method are considered, and the prospects of their application for wide-scale structural studies \textit{in vivo} are discussed.
The bibliography includes 145 references.