Home / Articles / Dihydropyrimidin-$2(1H)$-one and its analogues as a platform for the design and synthesis of new biologically active compounds

Dihydropyrimidin-$2(1H)$-one and its analogues as a platform for the design and synthesis of new biologically active compounds

Oleg Pavlovich Shkurko 1
Oleg Pavlovich Shkurko
, 
Tat'yana Genrikhovna Tolstikova 1
Tat'yana Genrikhovna Tolstikova
, 
Valentina Fedorovna Sedova 1
Valentina Fedorovna Sedova
1 N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistryof the Siberian Branch of Russian Academy of Sciences
10.1070/RCR4586
Published 30 November 2015
Communication , Volume 85, Issue 10, 1056-1096
17
Share
Cite this
GOST
 | 
Cite this
GOST
Copy cite
Shkurko O. P., Tolstikova T. G., Sedova V. F. Dihydropyrimidin-$2(1H)$-one and its analogues as a platform for the design and synthesis of new biologically active compounds // Russian Chemical Reviews. 2016. Vol. 85. No. 10. pp. 1056-1096.
GOST all authors (up to 50)
Copy cite
Shkurko O. P., Tolstikova T. G., Sedova V. F. Dihydropyrimidin-$2(1H)$-one and its analogues as a platform for the design and synthesis of new biologically active compounds // Russian Chemical Reviews. 2016. Vol. 85. No. 10. pp. 1056-1096.
RIS
 | 
Cite this
RIS
Copy cite
TY - JOUR
DO - 10.1070/RCR4586
UR - https://rcr.colab.ws/publications/10.1070/RCR4586
TI - Dihydropyrimidin-$2(1H)$-one and its analogues as a platform for the design and synthesis of new biologically active compounds
T2 - Russian Chemical Reviews
AU - Shkurko, Oleg Pavlovich
AU - Tolstikova, Tat'yana Genrikhovna
AU - Sedova, Valentina Fedorovna
PY - 2016
DA - 2015/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 1056-1096
IS - 10
VL - 85
ER -
BibTex
 | 
Cite this
BibTex (up to 50 authors)
Copy cite
@article{2016_Shkurko,
author = {Oleg Pavlovich Shkurko and Tat'yana Genrikhovna Tolstikova and Valentina Fedorovna Sedova},
title = {Dihydropyrimidin-$2(1H)$-one and its analogues as a platform for the design and synthesis of new biologically active compounds},
journal = {Russian Chemical Reviews},
year = {2016},
volume = {85},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR4586},
number = {10},
pages = {1056--1096},
doi = {10.1070/RCR4586}
}
MLA
Cite this
MLA
Copy cite
Shkurko, Oleg Pavlovich, et al. “Dihydropyrimidin-$2(1H)$-one and its analogues as a platform for the design and synthesis of new biologically active compounds.” Russian Chemical Reviews, vol. 85, no. 10, Nov. 2016, pp. 1056-1096. https://rcr.colab.ws/publications/10.1070/RCR4586.
Views / Visits / Downloads
20 / 20 / 4

Abstract

The data published mainly over two past decades on various types of biological activity of 5-functionally substituted 3,4-dihydropyrimidin-2-ones and their analogues, 2-thiones and 2-imines, and more complex dihydropyrimidine derivatives are summarized. Apart from medicinal chemistry issues, including structure--activity relationships, the pharmacological profiles of the most promising derivatives and the routes for further structural modification of known chemical compounds are discussed in general terms. Examples of potential uses of new compounds in medicine as single pharmaceutical agents and as parts of compositions are given.

The bibliography includes 334 references.

Funders

Russian Academy of Sciences
0302-2015-0001