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Chitosan and its derivatives: vectors in gene therapy

Andrey Sergeevich Kritchenkov 1, 2
Andrey Sergeevich Kritchenkov
, 
S Andranovitš 3
S Andranovitš
, 
Yury Andreevich Skorik 1, 4
Yury Andreevich Skorik
1 Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg
2 St. Petersburg State University, Institute of Chemistry
3 University of Vienna, Austria
4 Institute of Experimental Medicine, Federal V. A. Almazov North-West Medical Research Centre, Saint Petersburg
10.1070/RCR4636
Published 30 November 2016
Review , RCR4636, Volume 86, Issue 3, 231-239
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Kritchenkov A. S., Andranovitš S., Skorik Y. A. Chitosan and its derivatives: vectors in gene therapy // Russian Chemical Reviews. 2016. Vol. 86. No. 3. pp. 231-239.
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Kritchenkov A. S., Andranovitš S., Skorik Y. A. Chitosan and its derivatives: vectors in gene therapy // Russian Chemical Reviews. 2016. Vol. 86. No. 3. pp. 231-239.
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TY - JOUR
DO - 10.1070/RCR4636
UR - https://rcr.colab.ws/publications/10.1070/RCR4636
TI - Chitosan and its derivatives: vectors in gene therapy
T2 - Russian Chemical Reviews
AU - Kritchenkov, Andrey Sergeevich
AU - Andranovitš, S
AU - Skorik, Yury Andreevich
PY - 2016
DA - 2016/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 231-239
IS - 3
VL - 86
ER -
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@article{2016_Kritchenkov,
author = {Andrey Sergeevich Kritchenkov and S Andranovitš and Yury Andreevich Skorik},
title = {Chitosan and its derivatives: vectors in gene therapy},
journal = {Russian Chemical Reviews},
year = {2016},
volume = {86},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR4636},
number = {3},
pages = {231--239},
doi = {10.1070/RCR4636}
}
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Kritchenkov, Andrey Sergeevich, et al. “Chitosan and its derivatives: vectors in gene therapy.” Russian Chemical Reviews, vol. 86, no. 3, Nov. 2016, pp. 231-239. https://rcr.colab.ws/publications/10.1070/RCR4636.
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Abstract

The review deals with the use of chitosan and its derivatives as vectors for delivery of nucleic acids in gene therapy. Factors influencing the transfection efficiency of chitosan-based polyplexes (molecular weight, the degree of deacetylation, pH, type of chemical modification, type of transfected cells) are discussed. Particular attention is paid to methods of chemical modification of chitosan (covalent hydrophilic and hydrophobic modification and non-covalent modification), which are able to increase the transfection efficiency and to provide targeted delivery of nucleic acids.

The bibliography includes 151 references.

Funders

Russian Foundation for Basic Research
16-34-60173
Saint Petersburg State University
2.38.220.2015