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Development of liver cell-targeted drug delivery systems: experimental approaches

Yan Andreevich Ivanenkov 1, 2
Yan Andreevich Ivanenkov
, 
Svetlana Yur'evna Maklakova 1
Svetlana Yur'evna Maklakova
,  , 
Nikolai Vasil'evich Zyk 1
Nikolai Vasil'evich Zyk
, 
Anton Gerasimovich Nazarenko 3
Anton Gerasimovich Nazarenko
, 
Aleksandr Grigor'evich Tonevitsky 4, 5
Aleksandr Grigor'evich Tonevitsky
, 
Viktor Èlizarovich Kotelianski 6
Viktor Èlizarovich Kotelianski
, 
Alexander Georgievich Majouga 1, 3, 7
Alexander Georgievich Majouga
1 Lomonosov Moscow State University, Faculty of Chemistry
2 Moscow Institute of Physics and Technology (State University), Dolgoprudny, Moscow region
3 Clinical Hospital of General Management Department of the President of Russian Federation, Moscow
4 SNC Bioclinicum
5 P. A. Gertsen Moscow Research Oncology Institute, Moscow
6 Skolkovo Institute of Science and Technology
7 National University of Science and Technology «MISIS»
10.1070/RCR4707
Published 30 November 2016
Review , RCR4707, Volume 86, Issue 8, 750-776
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Ivanenkov Y. A. et al. Development of liver cell-targeted drug delivery systems: experimental approaches // Russian Chemical Reviews. 2016. Vol. 86. No. 8. pp. 750-776.
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Ivanenkov Y. A., Maklakova S. Y., Beloglazkina E. K., Zyk N. V., Nazarenko A. G., Tonevitsky A. G., Kotelianski V. È., Majouga A. G. Development of liver cell-targeted drug delivery systems: experimental approaches // Russian Chemical Reviews. 2016. Vol. 86. No. 8. pp. 750-776.
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TY - JOUR
DO - 10.1070/RCR4707
UR - https://rcr.colab.ws/publications/10.1070/RCR4707
TI - Development of liver cell-targeted drug delivery systems: experimental approaches
T2 - Russian Chemical Reviews
AU - Ivanenkov, Yan Andreevich
AU - Maklakova, Svetlana Yur'evna
AU - Beloglazkina, Elena Kimovna
AU - Zyk, Nikolai Vasil'evich
AU - Nazarenko, Anton Gerasimovich
AU - Tonevitsky, Aleksandr Grigor'evich
AU - Kotelianski, Viktor Èlizarovich
AU - Majouga, Alexander Georgievich
PY - 2016
DA - 2016/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 750-776
IS - 8
VL - 86
ER -
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@article{2016_Ivanenkov,
author = {Yan Andreevich Ivanenkov and Svetlana Yur'evna Maklakova and Elena Kimovna Beloglazkina and Nikolai Vasil'evich Zyk and Anton Gerasimovich Nazarenko and Aleksandr Grigor'evich Tonevitsky and Viktor Èlizarovich Kotelianski and Alexander Georgievich Majouga},
title = {Development of liver cell-targeted drug delivery systems: experimental approaches},
journal = {Russian Chemical Reviews},
year = {2016},
volume = {86},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR4707},
number = {8},
pages = {750--776},
doi = {10.1070/RCR4707}
}
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Ivanenkov, Yan Andreevich, et al. “Development of liver cell-targeted drug delivery systems: experimental approaches.” Russian Chemical Reviews, vol. 86, no. 8, Nov. 2016, pp. 750-776. https://rcr.colab.ws/publications/10.1070/RCR4707.
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Abstract

The review is devoted to liver cell-targeted drug delivery systems. Primary attention is paid to the therapy of hepatocellular carcinoma, liver fibrosis, liver cirrhosis, viral hepatitis (A--G), cholangiocarcinoma, autoimmune liver diseases and some metabolic disorders. A general overview, modern classification and specific features of drug delivery systems are presented. The key characteristics and parameters of these systems and their advantages and restrictions for clinical applications are discussed. A considerable body of information is presented as summary tables convenient for perception and comparison. The data presented are critically analyzed and an expert evaluation of the therapeutic potential of the drug delivery systems in question is given. Discussion of invasive local delivery approaches, transmembrane systems and implants, as well as prodrugs is beyond the scope of the review, except for a few examples.

The bibliography includes 344 references.

Funders

Russian Science Foundation
17-14-01316
Ministry of Education and Science of the Russian Federation
20.9907.2017/ВУ
National University of Science and Technology MISIS