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Targeted delivery of anti-tuberculosis drugs to macrophages: targeting mannose receptors

Lyubov Yur'evna Filatova 1
Lyubov Yur'evna Filatova
,  , 
Elena Vadimovna Kudryashova 1
Elena Vadimovna Kudryashova
1 Lomonosov Moscow State University, Faculty of Chemistry
10.1070/RCR4740
Published 30 November 2017
Review , RCR4740, Volume 87, Issue 4, 374-391
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Filatova L. Y., Klyachko N. L., Kudryashova E. V. Targeted delivery of anti-tuberculosis drugs to macrophages: targeting mannose receptors // Russian Chemical Reviews. 2017. Vol. 87. No. 4. pp. 374-391.
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Filatova L. Y., Klyachko N. L., Kudryashova E. V. Targeted delivery of anti-tuberculosis drugs to macrophages: targeting mannose receptors // Russian Chemical Reviews. 2017. Vol. 87. No. 4. pp. 374-391.
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TY - JOUR
DO - 10.1070/RCR4740
UR - https://rcr.colab.ws/publications/10.1070/RCR4740
TI - Targeted delivery of anti-tuberculosis drugs to macrophages: targeting mannose receptors
T2 - Russian Chemical Reviews
AU - Filatova, Lyubov Yur'evna
AU - Klyachko, Natalya L'vovna
AU - Kudryashova, Elena Vadimovna
PY - 2017
DA - 2017/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 374-391
IS - 4
VL - 87
ER -
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@article{2017_Filatova,
author = {Lyubov Yur'evna Filatova and Natalya L'vovna Klyachko and Elena Vadimovna Kudryashova},
title = {Targeted delivery of anti-tuberculosis drugs to macrophages: targeting mannose receptors},
journal = {Russian Chemical Reviews},
year = {2017},
volume = {87},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR4740},
number = {4},
pages = {374--391},
doi = {10.1070/RCR4740}
}
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Filatova, Lyubov Yur'evna, et al. “Targeted delivery of anti-tuberculosis drugs to macrophages: targeting mannose receptors.” Russian Chemical Reviews, vol. 87, no. 4, Nov. 2017, pp. 374-391. https://rcr.colab.ws/publications/10.1070/RCR4740.
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Abstract

The development of systems for targeted delivery of anti-tuberculosis drugs is a challenge of modern biotechnology. Currently, these drugs are encapsulated in a variety of carriers such as liposomes, polymers, emulsions and so on. Despite successful \textit{in vitro} testing of these systems, virtually no success was achieved \textit{in vivo}, because of low accessibility of the foci of infection located in alveolar macrophage cells. A promising strategy for increasing the efficiency of therapeutic action of anti-tuberculosis drugs is to encapsulate the agents into mannosylated carriers targeting the mannose receptors of alveolar macrophages. The review addresses the methods for modification of drug substance carriers, such as liposomes and biodegradable polymers, with mannose residues. The use of mannosylated carriers to deliver anti-tuberculosis agents increases the drug circulation time in the blood stream and increases the drug concentration in alveolar macrophage cells.

The bibliography includes 113 references.

Funders

Russian Science Foundation
15-13-00063

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