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Arbidol: a quarter-century later. Past, present and future of the original Russian antiviral

Konstantin Valer'evich Balakin 1, 2
Konstantin Valer'evich Balakin
, 
Rosanna Filosa 3, 4, 5
Rosanna Filosa
, 
Sergey Nikolaevich Lavrenov 6
Sergey Nikolaevich Lavrenov
, 
Arthur Sergeyevich Mkrtchayn 7
Arthur Sergeyevich Mkrtchayn
, 
Maxim Borisovich Nawrozkij 7
Maxim Borisovich Nawrozkij
, 
1 I. M. Sechenov First Moscow State Medical University
2 Kazan (Volga region) Federal University
3 Department of Experimental Medicine, Section of Biotechnology, University of Campania "Luigi Vanvitelli", Italy
4 Consorzio Sannio Tech, Italy
5 Institute of Food Sciences, National Research Council, Italy
6 Gause Institute of New Antibiotics, Moscow
7 Volgograd State Technical University
10.1070/RCR4791
Published 30 November 2017
Review , RCR4791, Volume 87, Issue 6, 509-552
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Balakin K. V. et al. Arbidol: a quarter-century later. Past, present and future of the original Russian antiviral // Russian Chemical Reviews. 2017. Vol. 87. No. 6. pp. 509-552.
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Balakin K. V., Filosa R., Lavrenov S. N., Mkrtchayn A. S., Nawrozkij M. B., Novakov I. A. Arbidol: a quarter-century later. Past, present and future of the original Russian antiviral // Russian Chemical Reviews. 2017. Vol. 87. No. 6. pp. 509-552.
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TY - JOUR
DO - 10.1070/RCR4791
UR - https://rcr.colab.ws/publications/10.1070/RCR4791
TI - Arbidol: a quarter-century later. Past, present and future of the original Russian antiviral
T2 - Russian Chemical Reviews
AU - Balakin, Konstantin Valer'evich
AU - Filosa, Rosanna
AU - Lavrenov, Sergey Nikolaevich
AU - Mkrtchayn, Arthur Sergeyevich
AU - Nawrozkij, Maxim Borisovich
AU - Novakov, Ivan Aleksandrovich
PY - 2017
DA - 2017/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 509-552
IS - 6
VL - 87
ER -
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@article{2017_Balakin,
author = {Konstantin Valer'evich Balakin and Rosanna Filosa and Sergey Nikolaevich Lavrenov and Arthur Sergeyevich Mkrtchayn and Maxim Borisovich Nawrozkij and Ivan Aleksandrovich Novakov},
title = {Arbidol: a quarter-century later. Past, present and future of the original Russian antiviral},
journal = {Russian Chemical Reviews},
year = {2017},
volume = {87},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR4791},
number = {6},
pages = {509--552},
doi = {10.1070/RCR4791}
}
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Balakin, Konstantin Valer'evich, et al. “Arbidol: a quarter-century later. Past, present and future of the original Russian antiviral.” Russian Chemical Reviews, vol. 87, no. 6, Nov. 2017, pp. 509-552. https://rcr.colab.ws/publications/10.1070/RCR4791.
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Abstract

The present review relates to the synthesis and structure-activity relationship studies of Arbidol and its structural analogues. The latter are roughly divided into several unequal parts: indole- and benzofuran-based compounds, benzimidazole and imidazopyridine bioisosteres, and ring-expanded quinoline derivatives. Much attention is focused on various types of antiviral activity of the above-mentioned Arbidol congeners, as well as of the parent compound itself. Features of Arbidol synthesis and metabolic changes are also discussed.

Bibliography --- 166 references.

Funders

Russian Foundation for Basic Research
16-33-6003 mol_a_dk
Ministry of Education and Science of the Russian Federation

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