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Analysis of exhaled air for early-stage diagnosis of lung cancer: opportunities and challenges

Aleksandr Akhatovich Ganeev 1, 2, 3
Aleksandr Akhatovich Ganeev
, 
Anna Romanovna Gubal 1
Anna Romanovna Gubal
, 
Gennadij Nikolaevich Lukyanov 2
Gennadij Nikolaevich Lukyanov
, 
Andrey Ivanovich Arseniev 4
Andrey Ivanovich Arseniev
, 
Anton Alekseevich Barchuk 4, 5
Anton Alekseevich Barchuk
, 
Igor Eduardovich Jahatspanian 2
Igor Eduardovich Jahatspanian
, 
Ilja Sergeevich Gorbunov 1
Ilja Sergeevich Gorbunov
, 
Anna Aleksandrovna Rassadina 2
Anna Aleksandrovna Rassadina
, 
Valerii Mikhailovich Nemets 1
Valerii Mikhailovich Nemets
, 
Andrey Olegovich Nefedov 4
Andrey Olegovich Nefedov
, 
Boris Aleksandrovich Korotetsky 3
Boris Aleksandrovich Korotetsky
, 
Nikolay Dmitrievich Solovyev 1
Nikolay Dmitrievich Solovyev
, 
Evgenia Iakovleva 6
Evgenia Iakovleva
, 
Natalja Borisovna Ivanenko 3
Natalja Borisovna Ivanenko
, 
Aleksandr Stanislavovich Kononov 1
Aleksandr Stanislavovich Kononov
, 
Mika Sillanpaa 6, 7
Mika Sillanpaa
, 
Thomas Seeger 8
Thomas Seeger
1 Saint Petersburg State University
2 St. Petersburg National Research University of Information Technologies, Mechanics and Optics
3 Institute of Toxicology, St. Petersburg
4 N. N. Petrov Research Institute of Oncology, Saint-Petersburg
5 Faculty of Social Sciences, Health Sciences, University of Tampere, Finland
6 Department of Green Chemistry, School of Engineering Science, Lappeenranta University of Technology, Finland
7 Department of Civil Engineering, Florida International University, USA
8 University of Siegen, Germany
10.1070/RCR4831
Published 30 November 2017
Review , RCR4831, Volume 87, Issue 9, 904-921
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Ganeev A. A. et al. Analysis of exhaled air for early-stage diagnosis of lung cancer: opportunities and challenges // Russian Chemical Reviews. 2017. Vol. 87. No. 9. pp. 904-921.
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Ganeev A. A., Gubal A. R., Lukyanov G. N., Arseniev A. I., Barchuk A. A., Jahatspanian I. E., Gorbunov I. S., Rassadina A. A., Nemets V. M., Nefedov A. O., Korotetsky B. A., Solovyev N. D., Iakovleva E., Ivanenko N. B., Kononov A. S., Sillanpaa M., Seeger T. Analysis of exhaled air for early-stage diagnosis of lung cancer: opportunities and challenges // Russian Chemical Reviews. 2017. Vol. 87. No. 9. pp. 904-921.
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TY - JOUR
DO - 10.1070/RCR4831
UR - https://rcr.colab.ws/publications/10.1070/RCR4831
TI - Analysis of exhaled air for early-stage diagnosis of lung cancer: opportunities and challenges
T2 - Russian Chemical Reviews
AU - Ganeev, Aleksandr Akhatovich
AU - Gubal, Anna Romanovna
AU - Lukyanov, Gennadij Nikolaevich
AU - Arseniev, Andrey Ivanovich
AU - Barchuk, Anton Alekseevich
AU - Jahatspanian, Igor Eduardovich
AU - Gorbunov, Ilja Sergeevich
AU - Rassadina, Anna Aleksandrovna
AU - Nemets, Valerii Mikhailovich
AU - Nefedov, Andrey Olegovich
AU - Korotetsky, Boris Aleksandrovich
AU - Solovyev, Nikolay Dmitrievich
AU - Iakovleva, Evgenia
AU - Ivanenko, Natalja Borisovna
AU - Kononov, Aleksandr Stanislavovich
AU - Sillanpaa, Mika
AU - Seeger, Thomas
PY - 2017
DA - 2017/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 904-921
IS - 9
VL - 87
ER -
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@article{2017_Ganeev,
author = {Aleksandr Akhatovich Ganeev and Anna Romanovna Gubal and Gennadij Nikolaevich Lukyanov and Andrey Ivanovich Arseniev and Anton Alekseevich Barchuk and Igor Eduardovich Jahatspanian and Ilja Sergeevich Gorbunov and Anna Aleksandrovna Rassadina and Valerii Mikhailovich Nemets and Andrey Olegovich Nefedov and Boris Aleksandrovich Korotetsky and Nikolay Dmitrievich Solovyev and Evgenia Iakovleva and Natalja Borisovna Ivanenko and Aleksandr Stanislavovich Kononov and Mika Sillanpaa and Thomas Seeger},
title = {Analysis of exhaled air for early-stage diagnosis of lung cancer: opportunities and challenges},
journal = {Russian Chemical Reviews},
year = {2017},
volume = {87},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR4831},
number = {9},
pages = {904--921},
doi = {10.1070/RCR4831}
}
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Ganeev, Aleksandr Akhatovich, et al. “Analysis of exhaled air for early-stage diagnosis of lung cancer: opportunities and challenges.” Russian Chemical Reviews, vol. 87, no. 9, Nov. 2017, pp. 904-921. https://rcr.colab.ws/publications/10.1070/RCR4831.
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Abstract

Early detection of lung cancer usually markedly increases the efficiency of therapy. However, the currently employed diagnostic approaches are not sufficiently effective, resulting in late detection of the disease and high patient mortality. Therefore, development of a high-throughput and reliable diagnostic method is a priority task requiring fast solution. Analysis of exhaled air for a number of organic compounds recognized as lung cancer biomarkers seems to be a promising approach for early diagnosis of the disease. This issue attracts growing interest, as indicated by increasing number of publications on this topic. This review surveys contemporary analytical techniques for analysis of exhaled air, including various spectroscopic and mass spectral methods and also gas sensor-based methods. The key benefits and shortcomings of the techniques, sample injection and pre-concentration methods, and the potential applicability of the methods for lung cancer detection are discussed. The prospects of simultaneous application of several analytical techniques and approaches for the early diagnosis are demonstrated.

The bibliography includes 147 references.

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