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Recent advances in antifungal drug discovery based on polyene macrolide antibiotics

Olga Aleksandrovna Omelchuk 1, 2
Olga Aleksandrovna Omelchuk
, 
Anna Nikolaevna Tevyashova 1, 2
Anna Nikolaevna Tevyashova
, 
Andrey Egorovich Shchekotikhin 1, 2
Andrey Egorovich Shchekotikhin
1 G. F. Gause Institute of New Antibiotics, Moscow
2 D. Mendeleev University of Chemical Technology of Russia, Moscow
10.1070/RCR4841
Published 30 November 2017
Review , RCR4841, Volume 87, Issue 12, 1206-1225
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Omelchuk O. A., Tevyashova A. N., Shchekotikhin A. E. Recent advances in antifungal drug discovery based on polyene macrolide antibiotics // Russian Chemical Reviews. 2017. Vol. 87. No. 12. pp. 1206-1225.
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Omelchuk O. A., Tevyashova A. N., Shchekotikhin A. E. Recent advances in antifungal drug discovery based on polyene macrolide antibiotics // Russian Chemical Reviews. 2017. Vol. 87. No. 12. pp. 1206-1225.
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TY - JOUR
DO - 10.1070/RCR4841
UR - https://rcr.colab.ws/publications/10.1070/RCR4841
TI - Recent advances in antifungal drug discovery based on polyene macrolide antibiotics
T2 - Russian Chemical Reviews
AU - Omelchuk, Olga Aleksandrovna
AU - Tevyashova, Anna Nikolaevna
AU - Shchekotikhin, Andrey Egorovich
PY - 2017
DA - 2017/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 1206-1225
IS - 12
VL - 87
ER -
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@article{2017_Omelchuk,
author = {Olga Aleksandrovna Omelchuk and Anna Nikolaevna Tevyashova and Andrey Egorovich Shchekotikhin},
title = {Recent advances in antifungal drug discovery based on polyene macrolide antibiotics},
journal = {Russian Chemical Reviews},
year = {2017},
volume = {87},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR4841},
number = {12},
pages = {1206--1225},
doi = {10.1070/RCR4841}
}
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Omelchuk, Olga Aleksandrovna, et al. “Recent advances in antifungal drug discovery based on polyene macrolide antibiotics.” Russian Chemical Reviews, vol. 87, no. 12, Nov. 2017, pp. 1206-1225. https://rcr.colab.ws/publications/10.1070/RCR4841.
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Abstract

The review summarizes recent advances in the synthesis of new derivatives of polyene macrolide antibiotics by chemical modification and genetic engineering methods, results of structure--activity relationship studies and progress in the development of effective and safe drug formulations of this class of antibiotics. Attention is focused on structural changes of polyenes, resulting in a significant decrease in toxicity with retention or even enhancement of antifungal activity. Current concepts on the mechanisms of biological action of these antiobiotics in terms of their therapeutic activity and toxicity are considered.

The bibliography includes 77 references.

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