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Aspartoacylase: a central nervous system enzyme. Structure, catalytic activity and regulation mechanisms

Ekaterina Dmitievna Kots 1, 2
Ekaterina Dmitievna Kots
, 
Mariya Grigor'evna Khrenova 1, 3
Mariya Grigor'evna Khrenova
, 
Alexander Vladimirovich Nemukhin 1, 2
Alexander Vladimirovich Nemukhin
, 
Sergei Dmitrievich Varfolomeev 1, 2
Sergei Dmitrievich Varfolomeev
1 Lomonosov Moscow State University, Faculty of Chemistry
2 Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow
3 Federal Research Centre "Fundamentals of Biotechnology" Russian Academy of Sciences, Moscow
10.1070/RCR4842
Published 30 November 2018
Review , RCR4842, Volume 88, Issue 1, 1-26
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Kots E. D. et al. Aspartoacylase: a central nervous system enzyme. Structure, catalytic activity and regulation mechanisms // Russian Chemical Reviews. 2018. Vol. 88. No. 1. pp. 1-26.
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Kots E. D., Khrenova M. G., Nemukhin A. V., Varfolomeev S. D. Aspartoacylase: a central nervous system enzyme. Structure, catalytic activity and regulation mechanisms // Russian Chemical Reviews. 2018. Vol. 88. No. 1. pp. 1-26.
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TY - JOUR
DO - 10.1070/RCR4842
UR - https://rcr.colab.ws/publications/10.1070/RCR4842
TI - Aspartoacylase: a central nervous system enzyme. Structure, catalytic activity and regulation mechanisms
T2 - Russian Chemical Reviews
AU - Kots, Ekaterina Dmitievna
AU - Khrenova, Mariya Grigor'evna
AU - Nemukhin, Alexander Vladimirovich
AU - Varfolomeev, Sergei Dmitrievich
PY - 2018
DA - 2018/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 1-26
IS - 1
VL - 88
ER -
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@article{2018_Kots,
author = {Ekaterina Dmitievna Kots and Mariya Grigor'evna Khrenova and Alexander Vladimirovich Nemukhin and Sergei Dmitrievich Varfolomeev},
title = {Aspartoacylase: a central nervous system enzyme. Structure, catalytic activity and regulation mechanisms},
journal = {Russian Chemical Reviews},
year = {2018},
volume = {88},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR4842},
number = {1},
pages = {1--26},
doi = {10.1070/RCR4842}
}
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Kots, Ekaterina Dmitievna, et al. “Aspartoacylase: a central nervous system enzyme. Structure, catalytic activity and regulation mechanisms.” Russian Chemical Reviews, vol. 88, no. 1, Nov. 2018, pp. 1-26. https://rcr.colab.ws/publications/10.1070/RCR4842.
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Abstract

Aspartoacylase is a key enzyme in the human central nervous system. Catalytic deficiency of aspartoacylase is associated with several neurodegenerative disorders, which accounts for the enhanced interest in description of the catalytic action and regulatory mechanisms of this enzyme. This review focuses on molecular modelling of the catalytic function of aspartoacylase and the ways of its allosteric regulation in terms of modern theoretical chemistry approaches. The conclusions based on experimental data on the structure and functions of aspartoacylase accumulated during the last 20 years and conclusions drawn from computer modelling results of the last 5 years are analyzed in detail.

The bibliography includes 109 references.

Funders

Russian Science Foundation
18-13-00030

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