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Synthesis of indoles: recent advances

Dmitry Ivanovich Bugaenko 1
Dmitry Ivanovich Bugaenko
, 
Alexander Vakhtangovich Karchava 1
Alexander Vakhtangovich Karchava
, 
Marina Abramovna Yurovskaya 1
Marina Abramovna Yurovskaya
1 Lomonosov Moscow State University, Faculty of Chemistry
10.1070/RCR4844
Published 30 November 2018
Review , RCR4844, Volume 88, Issue 2, 99-159
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Bugaenko D. I., Karchava A. V., Yurovskaya M. A. Synthesis of indoles: recent advances // Russian Chemical Reviews. 2018. Vol. 88. No. 2. pp. 99-159.
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Bugaenko D. I., Karchava A. V., Yurovskaya M. A. Synthesis of indoles: recent advances // Russian Chemical Reviews. 2018. Vol. 88. No. 2. pp. 99-159.
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TY - JOUR
DO - 10.1070/RCR4844
UR - https://rcr.colab.ws/publications/10.1070/RCR4844
TI - Synthesis of indoles: recent advances
T2 - Russian Chemical Reviews
AU - Bugaenko, Dmitry Ivanovich
AU - Karchava, Alexander Vakhtangovich
AU - Yurovskaya, Marina Abramovna
PY - 2018
DA - 2018/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 99-159
IS - 2
VL - 88
ER -
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@article{2018_Bugaenko,
author = {Dmitry Ivanovich Bugaenko and Alexander Vakhtangovich Karchava and Marina Abramovna Yurovskaya},
title = {Synthesis of indoles: recent advances},
journal = {Russian Chemical Reviews},
year = {2018},
volume = {88},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR4844},
number = {2},
pages = {99--159},
doi = {10.1070/RCR4844}
}
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Bugaenko, Dmitry Ivanovich, et al. “Synthesis of indoles: recent advances.” Russian Chemical Reviews, vol. 88, no. 2, Nov. 2018, pp. 99-159. https://rcr.colab.ws/publications/10.1070/RCR4844.
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Abstract

Published data of the last 10 years concerning the development of new and upgrading of known approaches to indole synthesis are integrated and analyzed. Modern versions of the classical syntheses such as the Fischer synthesis, Nenitzescu synthesis, Ullmann reaction, Leimgruber--Batcho synthesis, Reissert synthesis, Bartoli reaction, Madelung synthesis and Cadogan--Sundberg reaction are considered. The presented new approaches include transformations of heterocycles, synthesis from \textit{o}-alkynylanilines, reductive cyclization of nitrobenzene derivatives, synthesis with the use of arynes and catalysis by N-heterocyclic carbenes. The final Section summarizes original methods for the synthesis of indoles other than those listed above; they are classified in terms of the nature of the forming bond (C--C, C--N). Rarely used methods based on benzene ring construction in pyrrole derivatives are discussed separately.

The bibliography includes 246 references.

Funders

Russian Foundation for Basic Research
18-33-01100

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