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Main trends in the design of semi-synthetic antibiotics of a new generation

Evgeniya Nikolaevna Olsufyeva 1
Evgeniya Nikolaevna Olsufyeva
, 
Valentina Sergeevna Yankovskaya 2
Valentina Sergeevna Yankovskaya
1 G. F. Gause Institute of New Antibiotics, Moscow
2 Russian State Agrarian University - Moscow Agricultural Academy after K.A. Timiryazev, Moscow
10.1070/RCR4892
Published 30 November 2019
Review , RCR4892, Volume 89, Issue 3, 339-378
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Olsufyeva E. N., Yankovskaya V. S. Main trends in the design of semi-synthetic antibiotics of a new generation // Russian Chemical Reviews. 2019. Vol. 89. No. 3. pp. 339-378.
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Olsufyeva E. N., Yankovskaya V. S. Main trends in the design of semi-synthetic antibiotics of a new generation // Russian Chemical Reviews. 2019. Vol. 89. No. 3. pp. 339-378.
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TY - JOUR
DO - 10.1070/RCR4892
UR - https://rcr.colab.ws/publications/10.1070/RCR4892
TI - Main trends in the design of semi-synthetic antibiotics of a new generation
T2 - Russian Chemical Reviews
AU - Olsufyeva, Evgeniya Nikolaevna
AU - Yankovskaya, Valentina Sergeevna
PY - 2019
DA - 2019/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 339-378
IS - 3
VL - 89
ER -
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@article{2019_Olsufyeva,
author = {Evgeniya Nikolaevna Olsufyeva and Valentina Sergeevna Yankovskaya},
title = {Main trends in the design of semi-synthetic antibiotics of a new generation},
journal = {Russian Chemical Reviews},
year = {2019},
volume = {89},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR4892},
number = {3},
pages = {339--378},
doi = {10.1070/RCR4892}
}
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Olsufyeva, Evgeniya Nikolaevna, and Valentina Sergeevna Yankovskaya. “Main trends in the design of semi-synthetic antibiotics of a new generation.” Russian Chemical Reviews, vol. 89, no. 3, Nov. 2019, pp. 339-378. https://rcr.colab.ws/publications/10.1070/RCR4892.
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Abstract

This review summarizes main advances achieved by Russian researchers in the synthesis and characterization of semi-synthetic antibiotics of a new generation in the period 2004 to 2019. The following classes of compounds are considered as the basis for modification: polycyclic antibacterial glycopeptides of the vancomycin group, classical macrolides, antifungal polyene macrolides, the antitumour antibiotic olivomycin A, antitumour anthracyclines and broad-spectrum antibiotics, in particular, oligomycin A, heliomycin and some other. Main trends in the design of modern anti-infective and antitumour agents over this period are considered in relation to original natural antibiotics, which have been independently discovered by Russian researchers. It is shown that hybrid structures of a new type can, in principle, be synthesized based on glycopeptides, macrolides and other antibiotics, including heterodimers containing a new benzoxaborole pharmacophore. The review addresses the influence of the length of the spacer between two antibiotic molecules on the biological activity of hybrid structures. A combination of genetic engineering techniques and methods of organic synthesis is shown to be useful for the design of new potent antifungal antibiotics based on polyenes of the amphotericin B group. Many new semi-synthetic analogues exhibit important biological properties, such as a broad spectrum of activity and low toxicity. Emphasis is given to certain aspects related to investigation of a broad range of biological activity and mechanisms of action of new derivatives.

Bibliography --- 101 references.

Funders

Russian Foundation for Basic Research
06-04-08127-офи
Russian Science Foundation
15-15-00141-П
Ministry of Education and Science of the Russian Federation
02.512.12.2056
Foundation for the Promotion of Domestic Medicine
02.120.11.24179
Moscow Grant in the Field of Education Science and Technology

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