Home / Articles / Natural and synthetic cytokinins and their applications in biotechnology, agrochemistry and medicine

Natural and synthetic cytokinins and their applications in biotechnology, agrochemistry and medicine

, 
Antonida Vladimirovna Kalistratova 1
Antonida Vladimirovna Kalistratova
, 
Ekaterina Mikhailovna Savelieva 2
Ekaterina Mikhailovna Savelieva
, 
Georgii Aleksandrovich Romanov 2, 3
Georgii Aleksandrovich Romanov
, 
Natalia Anatolievna Bystrova 4
Natalia Anatolievna Bystrova
, 
Konstantin Aleksandrovich Kochetkov 1, 4
Konstantin Aleksandrovich Kochetkov
1 D. Mendeleev University of Chemical Technology of Russia, Moscow
2 Timiryazev Institute of Plant Physiology of RAS, Moscow
3 Lomonosov Moscow State University, Belozersky Research Institute of Physico-Chemical Biology
4 A. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, Moscow
10.1070/RCR4921
Published 30 November 2019
Review , RCR4921, Volume 89, Issue 8, 787-810
48
Share
Cite this
GOST
 | 
Cite this
GOST
Copy cite
Oshchepkov M. S. et al. Natural and synthetic cytokinins and their applications in biotechnology, agrochemistry and medicine // Russian Chemical Reviews. 2019. Vol. 89. No. 8. pp. 787-810.
GOST all authors (up to 50)
Copy cite
Oshchepkov M. S., Kalistratova A. V., Savelieva E. M., Romanov G. A., Bystrova N. A., Kochetkov K. A. Natural and synthetic cytokinins and their applications in biotechnology, agrochemistry and medicine // Russian Chemical Reviews. 2019. Vol. 89. No. 8. pp. 787-810.
RIS
 | 
Cite this
RIS
Copy cite
TY - JOUR
DO - 10.1070/RCR4921
UR - https://rcr.colab.ws/publications/10.1070/RCR4921
TI - Natural and synthetic cytokinins and their applications in biotechnology, agrochemistry and medicine
T2 - Russian Chemical Reviews
AU - Oshchepkov, Maxim Sergeevich
AU - Kalistratova, Antonida Vladimirovna
AU - Savelieva, Ekaterina Mikhailovna
AU - Romanov, Georgii Aleksandrovich
AU - Bystrova, Natalia Anatolievna
AU - Kochetkov, Konstantin Aleksandrovich
PY - 2019
DA - 2019/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 787-810
IS - 8
VL - 89
ER -
BibTex
 | 
Cite this
BibTex (up to 50 authors)
Copy cite
@article{2019_Oshchepkov,
author = {Maxim Sergeevich Oshchepkov and Antonida Vladimirovna Kalistratova and Ekaterina Mikhailovna Savelieva and Georgii Aleksandrovich Romanov and Natalia Anatolievna Bystrova and Konstantin Aleksandrovich Kochetkov},
title = {Natural and synthetic cytokinins and their applications in biotechnology, agrochemistry and medicine},
journal = {Russian Chemical Reviews},
year = {2019},
volume = {89},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR4921},
number = {8},
pages = {787--810},
doi = {10.1070/RCR4921}
}
MLA
Cite this
MLA
Copy cite
Oshchepkov, Maxim Sergeevich, et al. “Natural and synthetic cytokinins and their applications in biotechnology, agrochemistry and medicine.” Russian Chemical Reviews, vol. 89, no. 8, Nov. 2019, pp. 787-810. https://rcr.colab.ws/publications/10.1070/RCR4921.
Views / Visits / Downloads
33 / 33 / 9

Keywords

agrochemistry
biotechnology
cosmetology
cytokinins
Heterocycles
medicine
substituted adenines
ureas

Abstract

The review is devoted to cytokinins --- classical plant hormones known for more than six decades. Nevertheless, different aspects of the action of cytokinins are still being investigated. Relevant studies produced interesting, often unexpected, results, which cast doubt on the old paradigms and open new prospects for the use of these phytohormones. Particular attention is given to recent advances in the applications of natural cytokinins and their synthetic analogues in biotechnology, agriculture, medicine and cosmetics. The chemical synthesis, properties and the possible use of artificial cytokinins are considered in detail. The review is aimed at researchers interested in the development and applications of new biologically active compounds with a wide spectrum of action on diverse biological objects, from plants to humans.

The bibliography includes 233 references.

Funders

Russian Foundation for Basic Research
17-04-00969
Ministry of Education and Science of the Russian Federation

References

1.
KINETIN, A CELL DIVISION FACTOR FROM DEOXYRIBONUCLEIC ACID1
Miller C.O., Skoog F., Von Saltza M.H., Strong F.M.
Journal of the American Chemical Society , 1955
2.
rcr_89_8_787bib2
Davies
2004
3.
How do cytokinins affect the cell?
Romanov G.A.
Russian Journal of Plant Physiology , 2009
4.
rcr_89_8_787bib4
Taiz
2010
5.
rcr_89_8_787bib5
Romanov
2012
6.
Cytokinin action in plant development
Werner T., Schmülling T.
Current Opinion in Plant Biology , 2009
7.
Kieber J.J., Schaller G.E.
The Arabidopsis Book , 2014
8.
Cytokinin - A Developing Story.
Wybouw B., De Rybel B.
Trends in Plant Science , 2019
9.
Cytokinin Nucleosides - Natural Compounds with a Unique Spectrum of Biological Activities
S. Drenichev M., E. Oslovsky V., N. Mikhailov S.
Current Topics in Medicinal Chemistry , 2016
10.
Synthesis of aromatic cytokinins for plant biotechnology
Plíhalová L., Vylíčilová H., Doležal K., Zahajská L., Zatloukal M., Strnad M.
New Biotechnology , 2016
11.
rcr_89_8_787bib11
Sivamani
2014
12.
Anti-cancer activities of cytokinin ribosides
Voller J., Béres T., Zatloukal M., Džubák P., Hajdúch M., Doležal K., Schmülling T., Miroslav S.
Phytochemistry Reviews , 2019
13.
Lomin S.N., Krivosheev D.M., Steklov M.Y., Osolodkin D.I., Romanov G.A.
Acta Naturae , 2012
14.
Plant membrane assays with cytokinin receptors underpin the unique role of free cytokinin bases as biologically active ligands
Lomin S.N., Krivosheev D.M., Steklov M.Y., Arkhipov D.V., Osolodkin D.I., Schmülling T., Romanov G.A.
Journal of Experimental Botany , 2015
15.
Cytokinin perception in potato: new features of canonical players
Lomin S.N., Myakushina Y.A., Kolachevskaya O.O., Getman I.A., Arkhipov D.V., Savelieva E.M., Osolodkin D.I., Romanov G.A.
Journal of Experimental Botany , 2018
16.
Distribution, biological activities, metabolism, and the conceivable function of cis-zeatin-type cytokinins in plants
Gajdošová S., Spíchal L., Kamínek M., Hoyerová K., Novák O., Dobrev P.I., Galuszka P., Klíma P., Gaudinová A., Žižková E., Hanuš J., Dančák M., Trávníček B., Pešek B., Krupička M., et. al.
Journal of Experimental Botany , 2011
17.
Roles of Arabidopsis ATP/ADP isopentenyltransferases and tRNA isopentenyltransferases in cytokinin biosynthesis
Miyawaki K., Tarkowski P., Matsumoto-Kitano M., Kato T., Sato S., Tarkowska D., Tabata S., Sandberg G., Kakimoto T.
Proceedings of the National Academy of Sciences of the United States of America , 2006
18.
rcr_89_8_787bib18
Bishop
2015
19.
Evolution of cytokinin biosynthesis and degradation
Frebort I., Kowalska M., Hluska T., Frebortova J., Galuszka P.
Journal of Experimental Botany , 2011
20.
Dual action of cytodef on stress effect of paraquat in winter rye plants
Semenova A.S., Lukatkin A.S.
Russian Journal of Plant Physiology , 2015
21.
Root-to-shoot signalling: integration of diverse molecules, pathways and functions
Shabala S., White R.G., Djordjevic M.A., Ruan Y., Mathesius U.
Functional Plant Biology , 2016
22.
Cytokinin signaling: from the ER or from the PM? That is the question!
Romanov G.A., Lomin S.N., Schmülling T.
New Phytologist , 2018
25.
Regulation of cytokinin biosynthesis, compartmentalization and translocation
Hirose N., Takei K., Kuroha T., Kamada-Nobusada T., Hayashi H., Sakakibara H.
Journal of Experimental Botany , 2007
26.
A novel two-component hybrid molecule regulates vascular morphogenesis of the Arabidopsis root.
Mähönen A.P., Bonke M., Kauppinen L., Riikonen M., Benfey P.N., Helariutta Y.
Genes and Development , 2000
27.
Identification of CRE1 as a cytokinin receptor from Arabidopsis
Inoue T., Higuchi M., Hashimoto Y., Seki M., Kobayashi M., Kato T., Tabata S., Shinozaki K., Kakimoto T.
Nature , 2001
28.
The Arabidopsis Sensor His-kinase, AHK4, Can Respond to Cytokinins
Suzuki T., Miwa K., Ishikawa K., Yamada H., Aiba H., Mizuno T.
Plant and Cell Physiology , 2001
29.
Novel Family of Sensor Histidine Kinase Genes in Arabidopsis thaliana
Ueguchi C., Koizumi H., Suzuki T., Mizuno T.
Plant and Cell Physiology , 2001
30.
The Arabidopsis AHK4 Histidine Kinase is a Cytokinin-Binding Receptor that Transduces Cytokinin Signals Across the Membrane
Yamada H., Suzuki T., Terada K., Takei K., Ishikawa K., Miwa K., Yamashino T., Mizuno T.
Plant and Cell Physiology , 2001
31.
The Cytokinin Receptors of Arabidopsis Are Located Mainly to the Endoplasmic Reticulum    
Wulfetange K., Lomin S.N., Romanov G.A., Stolz A., Heyl A., Schmülling T.
Plant Physiology , 2011
32.
Ligand-binding properties and subcellular localization of maize cytokinin receptors
Lomin S.N., Yonekura-Sakakibara K., Romanov G.A., Sakakibara H.
Journal of Experimental Botany , 2011
33.
Studies of cytokinin receptor–phosphotransmitter interaction provide evidences for the initiation of cytokinin signalling in the endoplasmic reticulum
Lomin S.N., Myakushina Y.A., Arkhipov D.V., Leonova O.G., Popenko V.I., Schmülling T., Romanov G.A.
Functional Plant Biology , 2018
34.
Evidence for the localization of the Arabidopsis cytokinin receptors AHK3 and AHK4 in the endoplasmic reticulum
Caesar K., Thamm A.M., Witthöft J., Elgass K., Huppenberger P., Grefen C., Horak J., Harter K.
Journal of Experimental Botany , 2011
35.
CHASE-Containing Histidine Kinase Receptors in Apple Tree: From a Common Receptor Structure to Divergent Cytokinin Binding Properties and Specific Functions
Daudu D., Allion E., Liesecke F., Papon N., Courdavault V., Dugé de Bernonville T., Mélin C., Oudin A., Clastre M., Lanoue A., Courtois M., Pichon O., Giron D., Carpin S., Giglioli-Guivarc’h N., et. al.
Frontiers in Plant Science , 2017
36.
rcr_89_8_787bib36
Ding
Frontiers PlantSci. , 2017
39.
Structural basis for cytokinin receptor signaling: an evolutionary approach
Steklov M.Y., Lomin S.N., Osolodkin D.I., Romanov G.A.
Plant Cell Reports , 2013
40.
Evolutionary proteomics identifies amino acids essential for ligand-binding of the cytokinin receptor CHASE domain
Heyl A., Wulfetange K., Pils B., Nielsen N., Romanov G.A., Schmülling T.
BMC Evolutionary Biology , 2007
41.
The analysis of hormone-receptor interaction. Theoretical and practical aspects
Lomin S.N., Romanov G.A.
Russian Journal of Plant Physiology , 2008
44.
Structural Aspects of Multistep Phosphorelay-Mediated Signaling in Plants
Pekárová B., Szmitkowska A., Dopitová R., Degtjarik O., Žídek L., Hejátko J.
Molecular Plant , 2016
45.
Modeling of Protein–Protein Interactions in Cytokinin Signal Transduction
Arkhipov D.V., Lomin S.N., Myakushina Y.A., Savelieva E.M., Osolodkin D.I., Romanov G.A.
International Journal of Molecular Sciences , 2019
47.
Cytokinins Regulate a Bidirectional Phosphorelay Network in Arabidopsis
Mähönen A.P., Higuchi M., Törmäkangas K., Miyawaki K., Pischke M.S., Sussman M.R., Helariutta Y., Kakimoto T.
Current Biology , 2006
48.
Cytokinin Signaling and Its Inhibitor AHP6 Regulate Cell Fate During Vascular Development
Mähönen A.P., Bishopp A., Higuchi M., Nieminen K.M., Kinoshita K., Törmäkangas K., Ikeda Y., Oka A., Kakimoto T., Helariutta Y.
Science , 2006
49.
Cytokinin and the cell cycle
Schaller G.E., Street I.H., Kieber J.J.
Current Opinion in Plant Biology , 2014
50.
Regulation of plant growth by cytokinin
Werner T., Motyka V., Strnad M., Schmülling T.
Proceedings of the National Academy of Sciences of the United States of America , 2001
54.
Cytokinin signaling
Ferreira F.J., Kieber J.J.
Current Opinion in Plant Biology , 2005
55.
rcr_89_8_787bib55
Koshimizu
1986
56.
A live cell hormone-binding assay on transgenic bacteria expressing a eukaryotic receptor protein
Romanov G.A., Spíchal L., Lomin S.N., Strnad M., Schmülling T.
Analytical Biochemistry , 2005
57.
High Throughput Screening Method for Identifying Potential Agonists and Antagonists of Arabidopsis thaliana Cytokinin Receptor CRE1/AHK4
Klimeš P., Turek D., Mazura P., Gallová L., Spíchal L., Brzobohatý B.
Frontiers in Plant Science , 2017
58.
Cytokinin activity of N6-benzyladenine derivatives assayed by interaction with the receptors in planta, in vitro, and in silico
Savelieva E.M., Oslovsky V.E., Karlov D.S., Kurochkin N.N., Getman I.A., Lomin S.N., Sidorov G.V., Mikhailov S.N., Osolodkin D.I., Romanov G.A.
Phytochemistry , 2018
59.
Setting-up a fast and reliable cytokinin biosensor based on a plant histidine kinase receptor expressed in Saccharomyces cerevisiae
Daudu D., Kisiala A., Werner Ribeiro C., Mélin C., Perrot L., Clastre M., Courdavault V., Papon N., Oudin A., Courtois M., Dugé de Bernonville T., Gaucher M., Degrave A., Lanoue A., Lanotte P., et. al.
Journal of Biotechnology , 2019
60.
The purine derivative PI-55 blocks cytokinin action via receptor inhibition
Spíchal L., Werner T., Popa I., Riefler M., Schmülling T., Strnad M.
FEBS Journal , 2008
61.
Cytokinin receptor antagonists derived from 6-benzylaminopurine
Nisler J., Zatloukal M., Popa I., Doležal K., Strnad M., Spíchal L.
Phytochemistry , 2010
62.
N6-(benzyloxymethyl)adenosine is a novel anticytokinin, an antagonist of cytokinin receptor CRE1/AHK4 of Arabidopsis
Krivosheev D.M., Kolyachkina S.V., Mikhailov S.N., Tararov V.I., Vanyushin B.F., Romanov G.A.
Doklady Biochemistry and Biophysics , 2012
65.
Cytokinins in Symbiotic Nodulation: When, Where, What For?
Gamas P., Brault M., Jardinaud M., Frugier F.
Trends in Plant Science , 2017
66.
rcr_89_8_787bib66
Gu
PlantSci. , 2018
67.
Multiple routes communicating nitrogen availability from roots to shoots: a signal transduction pathway mediated by cytokinin
Takei K., Takahashi T., Sugiyama T., Yamaya T., Sakakibara H.
Journal of Experimental Botany , 2002
68.
Canopy light and nitrogen distributions are related to grain yield and nitrogen use efficiency in rice
Gu J., Chen Y., Zhang H., Li Z., Zhou Q., Yu C., Kong X., Liu L., Wang Z., Yang J.
Field Crops Research , 2017
69.
Cytokinin at the Crossroads of Abiotic Stress Signalling Pathways
Pavlů J., Novák J., Koukalová V., Luklová M., Brzobohatý B., Černý M.
International Journal of Molecular Sciences , 2018
71.
The role of cytokinins in responses to water deficit in tobacco plants over-expressing trans-zeatin O-glucosyltransferase gene under 35S or SAG12 promoters
HAVLOVÁ M., DOBREV P.I., MOTYKA V., ŠTORCHOVÁ H., LIBUS J., DOBRÁ J., MALBECK J., GAUDINOVÁ A., VANKOVÁ R.
Plant, Cell and Environment , 2008
72.
Cytokinin action in response to abiotic and biotic stresses in plants
Cortleven A., Leuendorf J.E., Frank M., Pezzetta D., Bolt S., Schmülling T.
Plant, Cell and Environment , 2019
73.
Role of cytokinins in stress resistance of plants
Veselov D.S., Kudoyarova G.R., Kudryakova N.V., Kusnetsov V.V.
Russian Journal of Plant Physiology , 2017
74.
Cytokinins: Their Impact on Molecular and Growth Responses to Drought Stress and Recovery in Arabidopsis
Prerostova S., Dobrev P.I., Gaudinova A., Knirsch V., Körber N., Pieruschka R., Fiorani F., Brzobohatý B., černý M., Spichal L., Humplik J., Vanek T., Schurr U., Vankova R.
Frontiers in Plant Science , 2018
75.
Regulation of chloroplast development and function by cytokinin
Cortleven A., Schmülling T.
Journal of Experimental Botany , 2015
76.
Cytokinins: metabolism and function in plant adaptation to environmental stresses
Ha S., Vankova R., Yamaguchi-Shinozaki K., Shinozaki K., Tran L.P.
Trends in Plant Science , 2012
77.
Interactions between cytokinin signalling and abiotic stress responses
Zwack P.J., Rashotte A.M.
Journal of Experimental Botany , 2015
78.
Cytokinin Oxidase Regulates Rice Grain Production
Ashikari M., Sakakibara H., Lin S., Yamamoto T., Takashi T., Nishimura A., Angeles E.R., Qian Q., Kitano H., Matsuoka M.
Science , 2005
79.
Silencing of the HvCKX1 gene decreases the cytokinin oxidase/dehydrogenase level in barley and leads to higher plant productivity
Zalewski W., Galuszka P., Gasparis S., Orczyk W., Nadolska-Orczyk A.
Journal of Experimental Botany , 2010
80.
rcr_89_8_787bib80
Zhao
2019
81.
Flow of cytokinins through the environment
Stirk W.A., van Staden J.
Plant Growth Regulation , 2010
82.
Use of cytokinins as agrochemicals
Koprna R., De Diego N., Dundálková L., Spíchal L.
Bioorganic and Medicinal Chemistry , 2016
84.
rcr_89_8_787bib84
Nisler
2018
85.
Reduction of paraquat toxicity in maize leaves by benzyladenine
Durmuş N., Kadioğlu A.
Acta Biologica Hungarica , 2005
86.
Cytokinins for immunity beyond growth, galls and green islands.
Naseem M., Wölfling M., Dandekar T.
Trends in Plant Science , 2014
87.
Identification of Rhodococcus fascians cytokinins and their modus operandi to reshape the plant
Pertry I., Václavíková K., Depuydt S., Galuszka P., Spíchal L., Temmerman W., Stes E., Schmülling T., Kakimoto T., Van Montagu M.C., Strnad M., Holsters M., Tarkowski P., Vereecke D.
Proceedings of the National Academy of Sciences of the United States of America , 2009
89.
Plant hormone-mediated regulation of stress responses
Verma V., Ravindran P., Kumar P.P.
BMC Plant Biology , 2016
90.
Cytokinins and plant immunity: old foes or new friends?
Choi J., Choi D., Lee S., Ryu C., Hwang I.
Trends in Plant Science , 2011
92.
Comparative study of different cytokinins in the induction of morphogenesis in lentil (Lens culinaris Medik)
Fratini R., Ruiz M.L.
In Vitro Cellular and Developmental Biology - Plant , 2002
93.
Effect of cytokinins on in vitro multiplication of Sophora tonkinensis
Jana S., Sivanesan I., Jeong B.R.
Asian Pacific Journal of Tropical Biomedicine , 2013
94.
rcr_89_8_787bib94
Shah
J. Anim. Plant Sci. , 2015
96.
The molecular path to in vitro shoot regeneration
Motte H., Vereecke D., Geelen D., Werbrouck S.
Biotechnology Advances , 2014
98.
Effects of plant growth regulators on cell growth and alkaloids production by cell cultures of Lycopodiella inundata
Bienaimé C., Melin A., Bensaddek L., Attoumbré J., Nava-Saucedo E., Baltora-Rosset S.
Plant Cell, Tissue and Organ Culture , 2015
99.
rcr_89_8_787bib99
Govindaraju
J. Saudi Soc. Agric. Sci. , 2018
100.
Effect of indole-3-acetic acid and kinetin on tuberisation parameters of different cultivars and transgenic lines of potato in vitro
Romanov; G.A., Aksenova N.P., Konstantinova T.N., Golyanovskaya S.A., Kossmann J., Willmitzer L.
Plant Growth Regulation , 2000
102.
rcr_89_8_787bib102
Ebadi
Afr. J. Biotechnol. , 2011
103.
rcr_89_8_787bib103
104.
rcr_89_8_787bib104
105.
rcr_89_8_787bib105
106.
rcr_89_8_787bib106
107.
rcr_89_8_787bib107
108.
rcr_89_8_787bib108
109.
rcr_89_8_787bib109
110.
rcr_89_8_787bib110
111.
rcr_89_8_787bib111
112.
Preparation, biological activity and endogenous occurrence of N6-benzyladenosines
Doležal K., Popa I., Hauserová E., Spíchal L., Chakrabarty K., Novák O., Kryštof V., Voller J., Holub J., Strnad M.
Bioorganic and Medicinal Chemistry , 2007
113.
Anticancer activity of natural cytokinins: A structure–activity relationship study
Voller J., Zatloukal M., Lenobel R., Doležal K., Béreš T., Kryštof V., Spíchal L., Niemann P., Džubák P., Hajdúch M., Strnad M.
Phytochemistry , 2010
114.
rcr_89_8_787bib114
Voller
2017
115.
Kolyachkina S.V., Tararov V.I., Alexeev C.S., Krivosheev D.M., Romanov G.A., Stepanova E.V., Solomko E.S., Inshakov A.N., Mikhailov S.N.
Collection of Czechoslovak Chemical Communications , 2011
116.
Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases
Jordheim L.P., Durantel D., Zoulim F., Dumontet C.
Nature Reviews Drug Discovery , 2013
117.
CYTOKININS AS CHEMOTHERAPEUTIC AGENTS
Mittelman A., Evans J.T., Chheda G.B.
Annals of the New York Academy of Sciences , 1975
119.
rcr_89_8_787bib119
Ishii
Cell Growth Differ. , 2002
120.
rcr_89_8_787bib120
Tiedemann
J. Clin. Invest. , 2008
121.
Novel genetic alterations and their impact on target therapy response in head and neck squamous cell carcinoma
Jiang X., Ye J., Dong Z., Hu S., Xiao M.
Cancer Management and Research , 2019
122.
rcr_89_8_787bib122
Lee
PLoS ONE , 2012
123.
Azoloazines as A2a receptor antagonists. Structure–activity relationship
Savateev K.V., Ulomsky E.N., Butorin I.I., Charushin V.N., Rusinov V.L., Chupakhin O.N.
Russian Chemical Reviews , 2018
125.
rcr_89_8_787bib125
Wang
Turk. J. Haematol. , 2019
126.
rcr_89_8_787bib126
Othman
PLoS ONE , 2016
127.
rcr_89_8_787bib127
Li
Pakistan Vet. J. , 2016
128.
Kinetin Delays the Onset of Aging Characteristics in Human Fibroblasts
Rattan S.I., Clark B.F.
Biochemical and Biophysical Research Communications , 1994
130.
N6-benzyladenine and kinetin influence antioxidative stress parameters in human skin fibroblasts
Jabłońska-Trypuć A., Matejczyk M., Czerpak R.
Molecular and Cellular Biochemistry , 2016
131.
rcr_89_8_787bib131
McCullough
J. Drugs Dermat. , 2008
132.
rcr_89_8_787bib132
Tremaine
J. Drugs Dermat. , 2010
133.
Inhibitory Effect of Zeatin, Isolated from Fiatoua villosa, on Acetylcholinesterase Activity from PC12 Cells
Heo H., Hong S., Cho H., Hong B., Kim H., Kim E., Shin D.
Molecules and Cells , 2002
134.
A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1
Hertz N., Berthet A., Sos M., Thorn K., Burlingame A., Nakamura K., Shokat K.
Cell , 2013
135.
Kinetin Riboside and Its ProTides Activate the Parkinson’s Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization
Osgerby L., Lai Y., Thornton P.J., Amalfitano J., Le Duff C.S., Jabeen I., Kadri H., Miccoli A., Tucker J.H., Muqit M.M., Mehellou Y.
Journal of Medicinal Chemistry , 2017
137.
Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea
Wu J.J., Weinstein G.D., Kricorian G.J., Kormeili T., McCullough J.L.
Clinical and Experimental Dermatology , 2007
138.
N6-isopentenyladenosine affects cytotoxic activity and cytokines production by IL-2 activated NK cells and exerts topical anti-inflammatory activity in mice
Ciaglia E., Pisanti S., Picardi P., Laezza C., Sosa S., Tubaro A., Vitale M., Gazzerro P., Malfitano A.M., Bifulco M.
Pharmacological Research , 2014
139.
rcr_89_8_787bib139
Lee
Int. J. Clin. Exp. Med. , 2017
140.
Synthesis of a series of N6-substituted adenosines with activity against trypanosomatid parasites
Link A., Heidler P., Kaiser M., Brun R.
European Journal of Medicinal Chemistry , 2009
141.
Plant hormone cytokinins control cell cycle progression and plastid replication in apicomplexan parasites
Andrabi S.B., Tahara M., Matsubara R., Toyama T., Aonuma H., Sakakibara H., Suematsu M., Tanabe K., Nozaki T., Nagamune K.
Parasitology International , 2018
142.
Retardation of the Senescence of Cultured Human Diploid Fibroblasts by Carnosine
McFarland G.A., Holliday R.
Experimental Cell Research , 1994
143.
Idebenone: a new antioxidant - Part I. Relative assessment of oxidative stress protection capacity compared to commonly known antioxidants
McDaniel D.H., Neudecker B.A., DiNardo J.C., Lewis J.A., Maibach H.I.
Journal of Cosmetic Dermatology , 2005
144.
rcr_89_8_787bib144
Ji
Int. J. Mol. Med. , 2010
145.
An S., Cha H.J., Ko J., Han H., Kim S.Y., Kim K., Lee S.J., An I., Kim S., Youn H.J., Ahn K.J., Kim S.
Annals of Dermatology , 2017
146.
Anti-Aging Properties of Plant Stem Cell Extracts
Miastkowska M., Sikora E.
Cosmetics , 2018
147.
X-ray structure, NMR and stability-in-solution study of 6-(furfurylamino)-9-(tetrahydropyran-2-yl)purine – A new active compound for cosmetology
Walla J., Szüčová L., Císařová I., Gucký T., Zatloukal M., Doležal K., Greplová J., Massino F.J., Strnad M.
Journal of Molecular Structure , 2010
148.
rcr_89_8_787bib148
Ortiz
J. Drugs Dermat. , 2009
149.
New cytokinin derivatives possess UVA and UVB photoprotective effect on human skin cells and prevent oxidative stress.
Hönig M., Plíhalová L., Spíchal L., Grúz J., Kadlecová A., Voller J., Svobodová A.R., Vostálová J., Ulrichová J., Doležal K., Strnad M.
European Journal of Medicinal Chemistry , 2018
150.
Synthesis and evaluation of in vitro anticancer activity of some novel isopentenyladenosine derivatives
Ottria R., Casati S., Manzocchi A., Baldoli E., Mariotti M., Maier J.A., Ciuffreda P.
Bioorganic and Medicinal Chemistry , 2010
152.
rcr_89_8_787bib152
Vankova
2014
153.
Benzimidazole nucleosides: antiviral and antitumour activities and methods of synthesis
Kharitonova M.I., Konstantinova I.D., Miroshnikov A.I.
Russian Chemical Reviews , 2018
154.
Synthesis of glycolurils and their analogues
Kravchenko A.N., Baranov V.V., Gazieva G.A.
Russian Chemical Reviews , 2018
156.
Synthesis and biological activity of some new N6-substituted purine nucleosides
Fleysher M.H., Bloch A., Hakala M.T., Nichol C.A.
Journal of Medicinal Chemistry , 1969
158.
Purines. LV. Syntheses and Cytokinin Activities of Some Adenine and Adenosine Derivatives Related to 1'-Methylzeatin.
FUJII T., OHBA M., KAWAMURA H., HANEISHI T., MATSUBARA S.
Chemical and Pharmaceutical Bulletin , 2011
159.
Phenyl-Adenine, Identified in aLIGHT-DEPENDENT SHORT HYPOCOTYLS4-Assisted Chemical Screen, Is a Potent Compound for Shoot Regeneration through the Inhibition of CYTOKININ OXIDASE/DEHYDROGENASE Activity    
Motte H., Galuszka P., Spíchal L., Tarkowski P., Plíhal O., Šmehilová M., Jaworek P., Vereecke D., Werbrouck S., Geelen D.
Plant Physiology , 2013
160.
Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells
Doležal K., Popa I., Kryštof V., Spíchal L., Fojtíková M., Holub J., Lenobel R., Schmülling T., Strnad M.
Bioorganic and Medicinal Chemistry , 2006
161.
C2-substituted aromatic cytokinin sugar conjugates delay the onset of senescence by maintaining the activity of the photosynthetic apparatus
Vylíčilová H., Husičková A., Spíchal L., Srovnal J., Doležal K., Plíhal O., Plíhalová L.
Phytochemistry , 2016
163.
Meta-topolin, a highly active aromatic cytokinin from poplar leaves (Populus × canadensis Moench., cv. Robusta)
Strnad M., Hanuš J., Vaněk T., Kamínek M., Ballantine J.A., Fussell B., Hanke D.E.
Phytochemistry , 1997
164.
Preparation, characterization and biological activity of C8-substituted cytokinins
Zahajská L., Nisler J., Voller J., Gucký T., Pospíšil T., Spíchal L., Strnad M.
Phytochemistry , 2017
165.
Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase
Zatloukal M., Gemrotová M., Doležal K., Havlíček L., Spíchal L., Strnad M.
Bioorganic and Medicinal Chemistry , 2008
166.
A novel inhibitor of cytokinin degradation (INCYDE) influences the biochemical parameters and photosynthetic apparatus in NaCl-stressed tomato plants
Aremu A.O., Masondo N.A., Sunmonu T.O., Kulkarni M.G., Zatloukal M., Spichal L., Doležal K., Van Staden J.
Planta , 2014
167.
Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives
Szüčová L., Spíchal L., Doležal K., Zatloukal M., Greplová J., Galuszka P., Kryštof V., Voller J., Popa I., Massino F.J., Jørgensen J., Strnad M.
Bioorganic and Medicinal Chemistry , 2009
170.
Novel Cytokinin Derivatives Do Not Show Negative Effects on Root Growth and Proliferation in Submicromolar Range
Podlešáková K., Zalabák D., Čudejková M., Plíhal O., Szüčová L., Doležal K., Spíchal L., Strnad M., Galuszka P.
PLoS ONE , 2012
171.
Question of the ribosyl moiety in the promotion of callus growth by exogenously added cytokinins
Hecht S.M., Bock R.M., Schmitz R.Y., Skoog F., Leonard N.J., Occolowitz J.L.
Biochemistry , 1971
172.
rcr_89_8_787bib172
Hecht
Plant Growth Subst , 1979
173.
Cytokinin and anticytokinin activity of some 4-substituted 1H-pyrazoles and 8-aza analogues of adenine
Karanov E., Alexieva V., Golovinsky E., Haimova M.
Plant Growth Regulation , 1993
174.
rcr_89_8_787bib174
George
2008
175.
rcr_89_8_787bib175
Yonova
General and Applied Plant Physiology , 2010
177.
Preparation and structure-activity relationships of 4-substituted amino-2-methylpyrido[3,4-d]pyrimidines as cytokinin analogs
Nishikawa S., Nishikimi Y., Maki S., Kumazawa Z., Kashimura N.
Journal of Agricultural and Food Chemistry , 1995
179.
rcr_89_8_787bib179
Genkov
Bulg. J. Plant Physiol. , 1995
182.
Novel thidiazuron-derived inhibitors of cytokinin oxidase/dehydrogenase
Nisler J., Kopečný D., Končitíková R., Zatloukal M., Bazgier V., Berka K., Zalabák D., Briozzo P., Strnad M., Spíchal L.
Plant Molecular Biology , 2016
183.
rcr_89_8_787bib183
Singh
Ind. J. Pharm. Sci. , 2018
184.
rcr_89_8_787bib184
185.
rcr_89_8_787bib185
186.
rcr_89_8_787bib186
188.
Convenient Synthesis and Cytokinin Activity of β-Substituted 4-Styrylpyridines, the Simplest Cytokinin Analogs with a Moderate Cell Division-Promoting Activity
Nishikawa S., Sato M., Kojima H., Suzuki C., Yamada N., Inagaki M., Kashimura N., Mizuno H.
Journal of Agricultural and Food Chemistry , 1996
189.
rcr_89_8_787bib189
190.
rcr_89_8_787bib190
194.
Protective Role of Kartolin-4 in Wheat Plants Exposed to Soil Draught
Monakhova O.F., Chernyad'ev I.I.
Applied Biochemistry and Microbiology , 2002
195.
rcr_89_8_787bib195
196.
rcr_89_8_787bib196
Baskakov
Agrikhimiya , 1988
197.
rcr_89_8_787bib197
198.
rcr_89_8_787bib198
Kovalenko
Butlerov Commun. , 2017
199.
Kovalenko L.V., Kalistratova A.V., Oshchepkov M.S., Glukhoedova E.A., Solovieva I.N., Vorob'ev M.M., Kochetkov K.A.
INEOS OPEN , 2018
200.
rcr_89_8_787bib200
Kovalenko
Bulg. J. Agric. Sci. , 2020
201.
rcr_89_8_787bib201
Kosarev
Russ. Med. Zh. , 2011
202.
rcr_89_8_787bib202
203.
rcr_89_8_787bib203
204.
rcr_89_8_787bib204
205.
rcr_89_8_787bib205
Hall
Cancer Res. , 1971
206.
Synthesis and biological activity of certain carbamoyl and alkoxycarbonyl derivatives of adenosine 3',5'-cyclic phosphate
Boswell K.H., Miller J.P., Shuman D.A., Sidwell R.W., Simon L.N., Robins R.K.
Journal of Medicinal Chemistry , 1973
207.
Synthesis and biological activity of analogs of naturally occurring 6-ureidopurines and their nucleosides
Hong C.I., Chheda G.B., Dutta S.P., O'Grady-Curtis A., Tritsch G.L.
Journal of Medicinal Chemistry , 1973
208.
Syntheses of cis-Zeatin and Its 9-(2-Deoxy-.BETA.-D-ribofuranosyl) Derivative. A Novel Synthetic Route to the Side Chain at C (6), and Cytokinin Activity.
EVIDENTE A., PICCIALLI G., SISTO A., OHBA M., HONDA K., FUJII T.
Chemical and Pharmaceutical Bulletin , 2011
209.
Tolman V., Hanuš J., Sedmera P.
Collection of Czechoslovak Chemical Communications , 2002
210.
A Novel Method for Synthesis of cis-Zeatin and Its Valuable Precursor (Z)-4-Chloro-2-methyl-but-2-en-1-ol
Hanuš J., Nisler J., Strnad M.
Organic Preparations and Procedures International , 2019
211.
Substituted Ureas. Methods of Synthesis and Applications
Vishnyakova T.P., Golubeva I.A., Glebova E.V.
Russian Chemical Reviews , 1985
212.
rcr_89_8_787bib212
Kalistratova
2017
213.
Novel one-pot synthesis of symmetrically substituted ureas
Wu X., Niu Q., Li T.
Synthetic Communications , 2016
215.
Microwave-assisted selective and efficient synthesis of 1,3,5-triazinyl mono and bisureas
Ruiz-Carretero A., Ramírez J.R., Sánchez-Migallón A., de la Hoz A.
Tetrahedron , 2014
216.
Broad-spectrum antiproliferative activity of a series of 6-(4-fluorophenyl)-5-(2-substituted pyrimidin-4-yl)imidazo[2,1-b]thiazole derivatives
Abdel-Maksoud M.S., El-Gamal M.I., Gamal El-Din M.M., Kwak S., Kim H., Oh C.
Medicinal Chemistry Research , 2016
217.
Scalable, One-Pot, Microwave-Accelerated Tandem Synthesis of Unsymmetrical Urea Derivatives
Kulkarni A.R., Garai S., Thakur G.A.
Journal of Organic Chemistry , 2016
218.
Antidepressant activity of carbamates and urea derivatives
Perveen S., Fatima N., Khan M.A., Dar A., Khan K.M., Afza N., Voelter W.
Medicinal Chemistry Research , 2011
220.
Microwave-assisted transamidation of ureas
Wang T.C., Qiao J.X.
Tetrahedron Letters , 2016
221.
Efficient Copper(II)-Catalyzed Transamidation of Non-Activated Primary Carboxamides and Ureas with Amines
Zhang M., Imm S., Bähn S., Neubert L., Neumann H., Beller M.
Angewandte Chemie - International Edition , 2012
222.
Unprecedented “In Water” Imidazole Carbonylation: Paradigm Shift for Preparation of Urea and Carbamate
Padiya K.J., Gavade S., Kardile B., Tiwari M., Bajare S., Mane M., Gaware V., Varghese S., Harel D., Kurhade S.
Organic Letters , 2012
223.
UNSYMMETRICAL UREAS. SYNTHETIC METHODOLOGIES AND APPLICATION IN DRUG DESIGN
Gallou I.
Organic Preparations and Procedures International , 2007
225.
rcr_89_8_787bib225
Perveen
J. Chem. Soc. Pakistan , 2010
227.
An unexpected reaction to methodology: an unprecedented approach to transamidation
Rakesh K.P., Ramesha A.B., Shantharam C.S., Mantelingu K., Mallesha N.
RSC Advances , 2016
228.
Methods of synthesis of nitrogen-containing heterocycles using ureas and related compounds
Bakibaev A.A., Yagovkin A.Y., Vostretsov S.N.
Russian Chemical Reviews , 1998
229.
rcr_89_8_787bib229
230.
Derivatives of arsonooxanilic acids and their biological activity
Petyunin P.A., Zakalyuzhnyi M.V.
Pharmaceutical Chemistry Journal , 1969
231.
Synthesis of benzimidazole-2-carboxylic acid amides from o-phenylenediamine and oxamic acid esters
Petyunin P.A., Choudry A.M.
Chemistry of Heterocyclic Compounds , 1982
232.
β-oxalylamino-substituted O-ethyl N-arylcarbamates and N-ethyl-N′-arylureas encapsulated into micelles of vinylimidazole–vinylcaprolactam copolymer
Vorob’ev M.M., Kovalenko L.V., Kalistratova A.V., Oshchepkov M.S., Filippova V.S., Khodak A.A., Kochetkov K.A.
Doklady Chemistry , 2017
233.
Encapsulation of chlorine-containing carbamates in polypeptide nanoparticles prepared by enzymatic hydrolysis of casein
Vorob’ev M.M., Khomenkov V.S., Sinitsyna O.V., Levinskaya O.A., Kitaeva D.K., Kalistratova A.V., Oshchepkov M.S., Kovalenko L.V., Kochetkov K.A.
Russian Chemical Bulletin , 2018