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Ligands of $\mathrm{G}$-quadruplex nucleic acids

Daria Vladimirovna Andreeva 1
Daria Vladimirovna Andreeva
, 
Alexander Sergeevich Tikhomirov 1, 2
Alexander Sergeevich Tikhomirov
, 
Andrey Egorovich Shchekotikhin 1, 2
Andrey Egorovich Shchekotikhin
1 G. F. Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, Moscow
2 D. Mendeleev University of Chemical Technology of Russia
10.1070/RCR4968
Published 30 November 2020
Review , RCR4968, Volume 90, Issue 1, 1-38
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Andreeva D. V., Tikhomirov A. S., Shchekotikhin A. E. Ligands of $\mathrm{G}$-quadruplex nucleic acids // Russian Chemical Reviews. 2020. Vol. 90. No. 1. pp. 1-38.
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Andreeva D. V., Tikhomirov A. S., Shchekotikhin A. E. Ligands of $\mathrm{G}$-quadruplex nucleic acids // Russian Chemical Reviews. 2020. Vol. 90. No. 1. pp. 1-38.
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TY - JOUR
DO - 10.1070/RCR4968
UR - https://rcr.colab.ws/publications/10.1070/RCR4968
TI - Ligands of $\mathrm{G}$-quadruplex nucleic acids
T2 - Russian Chemical Reviews
AU - Andreeva, Daria Vladimirovna
AU - Tikhomirov, Alexander Sergeevich
AU - Shchekotikhin, Andrey Egorovich
PY - 2020
DA - 2020/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 1-38
IS - 1
VL - 90
ER -
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@article{2020_Andreeva,
author = {Daria Vladimirovna Andreeva and Alexander Sergeevich Tikhomirov and Andrey Egorovich Shchekotikhin},
title = {Ligands of $\mathrm{G}$-quadruplex nucleic acids},
journal = {Russian Chemical Reviews},
year = {2020},
volume = {90},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR4968},
number = {1},
pages = {1--38},
doi = {10.1070/RCR4968}
}
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Andreeva, Daria Vladimirovna, et al. “Ligands of $\mathrm{G}$-quadruplex nucleic acids.” Russian Chemical Reviews, vol. 90, no. 1, Nov. 2020, pp. 1-38. https://rcr.colab.ws/publications/10.1070/RCR4968.
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Keywords

DNA
G-quadruplexes
ligands
low molecular weight compounds (small molecules)
nucleic acids
RNA

Abstract

The review summarizes advances in the development of low-molecular-weight ligands for $\mathrm{G}$-quadruplex $(\mathrm{G}4)$ nucleic acid structures published in the past five years. Main chemical classes of these ligands (polyaromatic compounds, macrocyclic systems, metal complexes and heterocyclic derivatives) are considered. The chemical structures of the ligands and their influence on the stabilization of quadruplexes are analyzed. Future prospects of design of $\mathrm{G}4$-ligands and their applications are discussed.

The bibliography includes 188 references.

Funders

Ministry of Education and Science of the Russian Federation

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