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Preservation of DNA for data storage

Xin Tan 1, 2, 3
Xin Tan
, 
Liqin Ge 2, 3
Liqin Ge
, 
Tianzhu Zhang 2, 3
Tianzhu Zhang
, 
Zuhong Lu 2, 3
Zuhong Lu
1 College of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, China
2 State Key Laboratory of Bioelectronics, Southeast University, Nanjing, China
3 National Demonstration Centre for Experimental Biomedical Engineering Education, School of Biological Science and Medical Engineering, Southeast University, China
Published 30 November 2020
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Tan X. et al. Preservation of DNA for data storage // Russian Chemical Reviews. 2020. Vol. 90. No. 2. pp. 280-291.
GOST all authors (up to 50)
Tan X., Ge L., Zhang T., Lu Z. Preservation of DNA for data storage // Russian Chemical Reviews. 2020. Vol. 90. No. 2. pp. 280-291.
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RIS
TY - JOUR
DO - 10.1070/RCR4994
UR - https://rcr.colab.ws/publications/10.1070/RCR4994
TI - Preservation of DNA for data storage
T2 - Russian Chemical Reviews
AU - Tan, Xin
AU - Ge, Liqin
AU - Zhang, Tianzhu
AU - Lu, Zuhong
PY - 2020
DA - 2020/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 280-291
IS - 2
VL - 90
ER -
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@article{2020_Tan,
author = {Xin Tan and Liqin Ge and Tianzhu Zhang and Zuhong Lu},
title = {Preservation of DNA for data storage},
journal = {Russian Chemical Reviews},
year = {2020},
volume = {90},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR4994},
number = {2},
pages = {280--291},
doi = {10.1070/RCR4994}
}
MLA
Cite this
MLA
Tan, Xin, et al. “Preservation of DNA for data storage.” Russian Chemical Reviews, vol. 90, no. 2, Nov. 2020, pp. 280-291. https://rcr.colab.ws/publications/10.1070/RCR4994.
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Keywords

DNA preservation; DNA data storage; DNA degradation; layer-by-layer; nanoparticles

Abstract

The preservation of DNA has attracted significant interest of scientists in diverse research fields from ancient biological remains to the information field. In light of the different DNA safekeeping requirements (\emph{e.g}., storage time, storage conditions) in these disparate fields, scientists have proposed distinct methods to maintain the DNA integrity. Specifically, DNA data storage is an emerging research, which means that the binary digital information is converted to the sequences of nucleotides leading to dense and durable data storage in the form of synthesized DNA. The intact preservation of DNA plays a significant role because it is closely related to data integrity. This review discusses DNA preservation methods, aiming to confirm an appropriate one for synthetic oligonucleotides in DNA data storage. First, we analyze the impact factors of the DNA long-term storage, including the intrinsic stability of DNA, environmental factors, and storage methods. Then, the benefits and disadvantages of diverse conservation approaches (\emph{e.g}., encapsulation-free, chemical encapsulation) are discussed. Finally, we provide advice for storing non-genetic information in DNA \emph{in vitro}. We expect these preservation suggestions to promote further research that may extend the DNA storage time.

The bibliography includes 99 references.

Funders

Science and Technology Department of Jiangsu Province key research and development projects
BE2017317

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