Home / Articles / Access to molecular complexity. Multicomponent reactions involving five or more components

Access to molecular complexity. Multicomponent reactions involving five or more components

Valentin Georgievich Nenajdenko 1
Valentin Georgievich Nenajdenko
1 Lomonosov Moscow State University, Faculty of Chemistry
10.1070/RCR5010
Published 30 November 2019
Review , RCR5010, Volume 89, Issue 11, 1274-1336
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Nenajdenko V. G. Access to molecular complexity. Multicomponent reactions involving five or more components // Russian Chemical Reviews. 2019. Vol. 89. No. 11. pp. 1274-1336.
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Nenajdenko V. G. Access to molecular complexity. Multicomponent reactions involving five or more components // Russian Chemical Reviews. 2019. Vol. 89. No. 11. pp. 1274-1336.
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TY - JOUR
DO - 10.1070/RCR5010
UR - https://rcr.colab.ws/publications/10.1070/RCR5010
TI - Access to molecular complexity. Multicomponent reactions involving five or more components
T2 - Russian Chemical Reviews
AU - Nenajdenko, Valentin Georgievich
PY - 2019
DA - 2019/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 1274-1336
IS - 11
VL - 89
ER -
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@article{2019_Nenajdenko,
author = {Valentin Georgievich Nenajdenko},
title = {Access to molecular complexity. Multicomponent reactions involving five or more components},
journal = {Russian Chemical Reviews},
year = {2019},
volume = {89},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR5010},
number = {11},
pages = {1274--1336},
doi = {10.1070/RCR5010}
}
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Nenajdenko, Valentin Georgievich. “Access to molecular complexity. Multicomponent reactions involving five or more components.” Russian Chemical Reviews, vol. 89, no. 11, Nov. 2019, pp. 1274-1336. https://rcr.colab.ws/publications/10.1070/RCR5010.
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Keywords

atomic accuracy
molecular complexity
Multicomponent reaction
structural diversity
synthesis

Abstract

The evaluation of the significance of a chemical transformation addresses many factors, including such important characteristics as the number of chemical bonds formed in one step, the reaction time, labour intensity, the cost of reactants and catalysts and so on. The amount of waste produced in the reaction has also gained increasing importance in recent years. Multicomponent reactions (MCRs) occupy a special place as a synthetic tool in modern organic chemistry. These reactions allow the synthesis of target products with complex structures, minimizing labour costs. This review summarizes the literature on multicomponent reactions involving five or more components. The data in the review are classified according to the number of reactants participating in the reaction and the types of reactions. It is worth noting that in some cases, these transformations can be a part of a domino process, making this classification difficult, if not impossible. The structural diversity of the reaction products greatly increases with increasing number of components involved in the MCR, which becomes virtually unlimited when using combinations of MCRs. This review highlights the main trends of past decades in the field of MCRs. The last two decades have witnessed an explosive growth in the number of publications in this area of chemistry.

The bibliography includes 309 references.

Funders

Russian Foundation for Basic Research
19-13-50171

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