Home / Articles / Coordination compounds of biogenic metals as cytotoxic agents in cancer therapy

Coordination compounds of biogenic metals as cytotoxic agents in cancer therapy

Dmitry Alexandrovich Guk 1
Dmitry Alexandrovich Guk
, 
Olga Olegovna Krasnovskaya 1
Olga Olegovna Krasnovskaya
, 
1 Lomonosov Moscow State University, Faculty of Chemistry
10.1070/RCR5016
Published 30 November 2020
Review , RCR5016, Volume 90, Issue 12, 1566-1623
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Guk D. A., Krasnovskaya O. O., Beloglazkina E. K. Coordination compounds of biogenic metals as cytotoxic agents in cancer therapy // Russian Chemical Reviews. 2020. Vol. 90. No. 12. pp. 1566-1623.
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Guk D. A., Krasnovskaya O. O., Beloglazkina E. K. Coordination compounds of biogenic metals as cytotoxic agents in cancer therapy // Russian Chemical Reviews. 2020. Vol. 90. No. 12. pp. 1566-1623.
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TY - JOUR
DO - 10.1070/RCR5016
UR - https://rcr.colab.ws/publications/10.1070/RCR5016
TI - Coordination compounds of biogenic metals as cytotoxic agents in cancer therapy
T2 - Russian Chemical Reviews
AU - Guk, Dmitry Alexandrovich
AU - Krasnovskaya, Olga Olegovna
AU - Beloglazkina, Elena Kimovna
PY - 2020
DA - 2020/11/30
PB - ANO Editorial Board of the journal Uspekhi Khimii
SP - 1566-1623
IS - 12
VL - 90
ER -
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@article{2020_Guk,
author = {Dmitry Alexandrovich Guk and Olga Olegovna Krasnovskaya and Elena Kimovna Beloglazkina},
title = {Coordination compounds of biogenic metals as cytotoxic agents in cancer therapy},
journal = {Russian Chemical Reviews},
year = {2020},
volume = {90},
publisher = {ANO Editorial Board of the journal Uspekhi Khimii},
month = {Nov},
url = {https://rcr.colab.ws/publications/10.1070/RCR5016},
number = {12},
pages = {1566--1623},
doi = {10.1070/RCR5016}
}
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Guk, Dmitry Alexandrovich, et al. “Coordination compounds of biogenic metals as cytotoxic agents in cancer therapy.” Russian Chemical Reviews, vol. 90, no. 12, Nov. 2020, pp. 1566-1623. https://rcr.colab.ws/publications/10.1070/RCR5016.
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Keywords

anticancer drugs
biogenic metals
coordination chemistry
organometallic compounds

Abstract

The review summarizes the data on the structures and methods for the synthesis of compounds with anticancer activity based on biogenic metals, which can replace platinum drugs prevailing in cytotoxic therapy. The main focus is given to the comparison of the mechanisms of the cytotoxic action of these complexes, their efficacy and prospects of their use in clinical practice. This is the first systematic review of cytotoxic zinc, iron, cobalt and copper compounds. The structure--activity relationships and the mechanisms of antitumour action are formulated for each type of metal complexes.

The bibliography includes 181 references.

Funders

Russian Foundation for Basic Research
20-13-50013

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