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Triarylphosphonium compounds as effective vectors for mitochondria-targeted delivery systems: decoration strategies and prospects for clinical application

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10.59761/RCR5095
2023-11-10 , Review , RCR5095, Volume 92, Issue 10
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Tatiana N. Pashirova et al. Triarylphosphonium compounds as effective vectors for mitochondria-targeted delivery systems: decoration strategies and prospects for clinical application // Russian Chemical Reviews. 2023. Vol. 92. No. 10. RCR5095
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Tatiana N. Pashirova, Andrey V. Nemtarev, Eliana B. Souto, Vladimir F. Mironov Triarylphosphonium compounds as effective vectors for mitochondria-targeted delivery systems: decoration strategies and prospects for clinical application // Russian Chemical Reviews. 2023. Vol. 92. No. 10. RCR5095
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TY - GENERIC
DO - 10.59761/RCR5095
UR - https://rcr.colab.ws/publications/10.59761/RCR5095
TI - Triarylphosphonium compounds as effective vectors for mitochondria-targeted delivery systems: decoration strategies and prospects for clinical application
T2 - Russian Chemical Reviews
PB - Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
AU - Pashirova, Tatiana N.
AU - Nemtarev, Andrey V.
AU - Souto, Eliana B.
AU - Mironov, Vladimir F.
PY - 2023
SP - RCR5095
IS - 10
VL - 92
ER -
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@misc{2023_Pashirova,
author = {Tatiana N. Pashirova and Andrey V. Nemtarev and Eliana B. Souto and Vladimir F. Mironov},
title = {Triarylphosphonium compounds as effective vectors for mitochondria-targeted delivery systems: decoration strategies and prospects for clinical application},
month = {nov},
year = {2023}
}
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Pashirova, Tatiana N., et al. “Triarylphosphonium compounds as effective vectors for mitochondria-targeted delivery systems: decoration strategies and prospects for clinical application.” Russian Chemical Reviews, vol. 92, no. 10, Nov. 2023, p. RCR5095. https://rcr.colab.ws/publications/10.59761/RCR5095.

Keywords

functionalization of nanoparticles
mitochondria-targeted nanoparticles
mitochondrial dysfunction
triphenylphosphonium
triphenylphosphonium-nanoparticles

Abstract

Mitochondrial dysfunctions lead to the emergence and development of a large number of diseases. The present review gives the first systematic survey of various aspects of studies of mitochondria-targeted nanosystems containing triphenylphosphonium vector groups providing targeted delivery of drug substances to these organelles. Approaches to the design of components and various nanoparticles bearing these groups are summarized and analyzed. The relationship between the key parameters of triphenylphosphonium nanoparticles (chemical composition, size, shape, ζ-potential, drug loading, drug encapsulation efficiency, etc.) and the biological action is discussed; in some cases, the mechanism of mitochondria targeting is given. The design principles and preparation methods for mitochondria-targeted triphenylphosphonium delivery nanosystems are of interest to researchers in the field of nanomaterials, nanotechnology, molecular biology, biotechnology and pharmaceutical chemistry.

The bibliography includes 243 references.